Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans

Mitochondrial dysfunction can increase oxidative stress and extend lifespan in Caenorhabditis elegans. Homeostatic mechanisms exist to cope with disruptions to mitochondrial function that promote cellular health and organismal longevity. Previously, we determined that decreased expression of the cyt...

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Detalles Bibliográficos
Autores principales: Bennett, Christopher F., Kwon, Jane J., Chen, Christine, Russell, Joshua, Acosta, Kathlyn, Burnaevskiy, Nikolay, Crane, Matthew M., Bitto, Alessandro, Vander Wende, Helen, Simko, Marissa, Pineda, Victor, Rossner, Ryan, Wasko, Brian M., Choi, Haeri, Chen, Shiwen, Park, Shirley, Jafari, Gholamali, Sands, Bryan, Perez Olsen, Carissa, Mendenhall, Alexander R., Morgan, Philip G., Kaeberlein, Matt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389855/
https://www.ncbi.nlm.nih.gov/pubmed/28355222
http://dx.doi.org/10.1371/journal.pgen.1006695

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