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Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study
BACKGROUND: Abnormal ankle-brachial index (ABI) has been found to be a strong predictor of mortality in some hemodialysis populations in studies with relatively short periods of follow-up, lower than 2 years. OBJECTIVE: This study aimed to assess the predictive value of abnormal ABI as a risk factor...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia - SBC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389869/ https://www.ncbi.nlm.nih.gov/pubmed/28443959 http://dx.doi.org/10.5935/abc.20170026 |
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author | Miguel, Jair Baptista de Matos, Jorge Paulo Strogoff Lugon, Jocemir Ronaldo |
author_facet | Miguel, Jair Baptista de Matos, Jorge Paulo Strogoff Lugon, Jocemir Ronaldo |
author_sort | Miguel, Jair Baptista |
collection | PubMed |
description | BACKGROUND: Abnormal ankle-brachial index (ABI) has been found to be a strong predictor of mortality in some hemodialysis populations in studies with relatively short periods of follow-up, lower than 2 years. OBJECTIVE: This study aimed to assess the predictive value of abnormal ABI as a risk factor for death among patients on maintenance hemodialysis after a 5-year follow-up. METHODS: A total of 478 patients on hemodialysis for at least 12 months were included in the study. ABI measurement was performed using a mercury column sphygmomanometer and portable Doppler. Patients were divided into 3 groups according to ABI (low: <0.9; normal: 0.9 to 1.3; and high: >1.3) and followed for a 60-month period. RESULTS: The prevalence rates of low, normal and high ABI were 26.8%, 64.6% and 8.6%, respectively. The 5-year survival rate was lower in the groups with low ABI (44.1%, P<0.0001) and high ABI (60.8%, P= 0.025) than in the group with normal ABI (71.7%). Cox regression was used to evaluate the association between ABI and mortality, adjusting for potential confounders. Using normal ABI as reference, a low, but not a high ABI was found to be an independent risk factor for all-cause mortality (HR2.57; 95% CI, 1.84-3.57 and HR 1.62; 95% CI, 0.93-2.83, respectively). CONCLUSIONS: long-term survival rates of patients with either low or high ABI were lower than the one from those with normal ABI. However, after adjustment for potential confounders, only low ABI persisted as an independent risk factor for all-cause mortality among hemodialysis patients. |
format | Online Article Text |
id | pubmed-5389869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Cardiologia - SBC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53898692017-04-18 Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study Miguel, Jair Baptista de Matos, Jorge Paulo Strogoff Lugon, Jocemir Ronaldo Arq Bras Cardiol Original Articles BACKGROUND: Abnormal ankle-brachial index (ABI) has been found to be a strong predictor of mortality in some hemodialysis populations in studies with relatively short periods of follow-up, lower than 2 years. OBJECTIVE: This study aimed to assess the predictive value of abnormal ABI as a risk factor for death among patients on maintenance hemodialysis after a 5-year follow-up. METHODS: A total of 478 patients on hemodialysis for at least 12 months were included in the study. ABI measurement was performed using a mercury column sphygmomanometer and portable Doppler. Patients were divided into 3 groups according to ABI (low: <0.9; normal: 0.9 to 1.3; and high: >1.3) and followed for a 60-month period. RESULTS: The prevalence rates of low, normal and high ABI were 26.8%, 64.6% and 8.6%, respectively. The 5-year survival rate was lower in the groups with low ABI (44.1%, P<0.0001) and high ABI (60.8%, P= 0.025) than in the group with normal ABI (71.7%). Cox regression was used to evaluate the association between ABI and mortality, adjusting for potential confounders. Using normal ABI as reference, a low, but not a high ABI was found to be an independent risk factor for all-cause mortality (HR2.57; 95% CI, 1.84-3.57 and HR 1.62; 95% CI, 0.93-2.83, respectively). CONCLUSIONS: long-term survival rates of patients with either low or high ABI were lower than the one from those with normal ABI. However, after adjustment for potential confounders, only low ABI persisted as an independent risk factor for all-cause mortality among hemodialysis patients. Sociedade Brasileira de Cardiologia - SBC 2017-03 /pmc/articles/PMC5389869/ /pubmed/28443959 http://dx.doi.org/10.5935/abc.20170026 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Miguel, Jair Baptista de Matos, Jorge Paulo Strogoff Lugon, Jocemir Ronaldo Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A 5-Year Cohort Study |
title | Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A
5-Year Cohort Study |
title_full | Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A
5-Year Cohort Study |
title_fullStr | Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A
5-Year Cohort Study |
title_full_unstemmed | Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A
5-Year Cohort Study |
title_short | Ankle-Brachial Index as a Predictor of Mortality in Hemodialysis: A
5-Year Cohort Study |
title_sort | ankle-brachial index as a predictor of mortality in hemodialysis: a
5-year cohort study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389869/ https://www.ncbi.nlm.nih.gov/pubmed/28443959 http://dx.doi.org/10.5935/abc.20170026 |
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