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Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment
Hyperphosphorylated tau has a critical role in tauopathies such as Alzheimer’s disease and frontotemporal dementia, impairing neuronal function and eventually leading to neurodegeneration. A critical role for tau is supported by studies in transgenic mouse models that express the P301L tau mutation...
Autores principales: | Hatch, Robert John, Wei, Yan, Xia, Di, Götz, Jürgen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389999/ https://www.ncbi.nlm.nih.gov/pubmed/28091722 http://dx.doi.org/10.1007/s00401-017-1674-1 |
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