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Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with “early” oligomeric Tau forms rather than mature neurofibrillary tangles (NFTs) cons...

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Detalles Bibliográficos
Autores principales:	Wang, Peng, Joberty, Gerard, Buist, Arjan, Vanoosthuyse, Alexandre, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Pierrot, Nathalie, Faelth-Savitski, Maria, Kienlen-Campard, Pascal, Octave, Jean-Noël, Bantscheff, Marcus, Drewes, Gerard, Moechars, Diederik, Dewachter, Ilse
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Original Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390007/ https://www.ncbi.nlm.nih.gov/pubmed/28083634 http://dx.doi.org/10.1007/s00401-016-1663-9

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