New potential eukaryotic substrates of the mycobacterial protein tyrosine phosphatase PtpA: hints of a bacterial modulation of macrophage bioenergetics state

The bacterial protein tyrosine phosphatase PtpA is a key virulence factor released by Mycobacterium tuberculosis in the cytosol of infected macrophages. So far only two unrelated macrophage components (VPS33B, GSK3α) have been identified as PtpA substrates. As tyrosine phosphatases are capable of us...

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Detalles Bibliográficos
Autores principales: Margenat, Mariana, Labandera, Anne-Marie, Gil, Magdalena, Carrion, Federico, Purificação, Marcela, Razzera, Guilherme, Portela, María Magdalena, Obal, Gonzalo, Terenzi, Hernán, Pritsch, Otto, Durán, Rosario, Ferreira, Ana María, Villarino, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390082/
https://www.ncbi.nlm.nih.gov/pubmed/25743628
http://dx.doi.org/10.1038/srep08819

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