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Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension

The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected biomarkers were assessed in control group, dyspnea group, and HF group. On ex...

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Autores principales: Bielecka-Dabrowa, Agata, Michalska-Kasiczak, Marta, Gluba, Anna, Ahmed, Ali, Gerdts, Eva, von Haehling, Stephan, Rysz, Jacek, Banach, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390083/
https://www.ncbi.nlm.nih.gov/pubmed/25747153
http://dx.doi.org/10.1038/srep08916
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author Bielecka-Dabrowa, Agata
Michalska-Kasiczak, Marta
Gluba, Anna
Ahmed, Ali
Gerdts, Eva
von Haehling, Stephan
Rysz, Jacek
Banach, Maciej
author_facet Bielecka-Dabrowa, Agata
Michalska-Kasiczak, Marta
Gluba, Anna
Ahmed, Ali
Gerdts, Eva
von Haehling, Stephan
Rysz, Jacek
Banach, Maciej
author_sort Bielecka-Dabrowa, Agata
collection PubMed
description The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected biomarkers were assessed in control group, dyspnea group, and HF group. On exercise dyspnea patients had lower early diastolic (E') and systolic (S') mitral annular velocity (12.8 ± 1.0 vs 14.9 ± 3.0 cm/sec and 9.3 ± 2.0 vs 10.9 ± 2.0 cm/sec, respectively), and higher E/E' ratio compared to control group (6.7 ± 1.0 vs 5.9 ± 1.0) (p < 0.05 for all comparisons). The level of N-terminal propeptide of procollagen type III (PIIINP) was significantly higher in dyspnea group than in controls (p = 0.01). Control and dyspnea patients had lower levels of cardiotrophin-1, cystatin C, syndecan-4, and N terminal–probrain natriuretic peptide than HF patients (all p ≤ 0.01). In multivariate analysis PIIINP (unadjusted odds ratio [OR] = 8.2, 95% confidence interval [Cl] 1.7–40.6; p = 0.001; adjusted OR = 8.7; 95%CI: 1.5–48.3; p = 0.001) and E/E' ratio on exercise (unadjusted OR = 1.8, 95%CI: 0.8–4.0; p = 0.033; adjusted OR = 2.0; 95%CI: 0.8–4.8; p = 0.012) were the only factors significantly associated with the presence of dyspnea. PIIINP is the first early biomarker for the HF development in patients with HA and normal resting echocardiography. Exertional echocardiography may indicate patients with incipient HF with preserved ejection fraction.
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spelling pubmed-53900832017-04-14 Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension Bielecka-Dabrowa, Agata Michalska-Kasiczak, Marta Gluba, Anna Ahmed, Ali Gerdts, Eva von Haehling, Stephan Rysz, Jacek Banach, Maciej Sci Rep Article The study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected biomarkers were assessed in control group, dyspnea group, and HF group. On exercise dyspnea patients had lower early diastolic (E') and systolic (S') mitral annular velocity (12.8 ± 1.0 vs 14.9 ± 3.0 cm/sec and 9.3 ± 2.0 vs 10.9 ± 2.0 cm/sec, respectively), and higher E/E' ratio compared to control group (6.7 ± 1.0 vs 5.9 ± 1.0) (p < 0.05 for all comparisons). The level of N-terminal propeptide of procollagen type III (PIIINP) was significantly higher in dyspnea group than in controls (p = 0.01). Control and dyspnea patients had lower levels of cardiotrophin-1, cystatin C, syndecan-4, and N terminal–probrain natriuretic peptide than HF patients (all p ≤ 0.01). In multivariate analysis PIIINP (unadjusted odds ratio [OR] = 8.2, 95% confidence interval [Cl] 1.7–40.6; p = 0.001; adjusted OR = 8.7; 95%CI: 1.5–48.3; p = 0.001) and E/E' ratio on exercise (unadjusted OR = 1.8, 95%CI: 0.8–4.0; p = 0.033; adjusted OR = 2.0; 95%CI: 0.8–4.8; p = 0.012) were the only factors significantly associated with the presence of dyspnea. PIIINP is the first early biomarker for the HF development in patients with HA and normal resting echocardiography. Exertional echocardiography may indicate patients with incipient HF with preserved ejection fraction. Nature Publishing Group 2015-03-09 /pmc/articles/PMC5390083/ /pubmed/25747153 http://dx.doi.org/10.1038/srep08916 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Bielecka-Dabrowa, Agata
Michalska-Kasiczak, Marta
Gluba, Anna
Ahmed, Ali
Gerdts, Eva
von Haehling, Stephan
Rysz, Jacek
Banach, Maciej
Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension
title Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension
title_full Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension
title_fullStr Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension
title_full_unstemmed Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension
title_short Biomarkers and Echocardiographic Predictors of Myocardial Dysfunction in Patients with Hypertension
title_sort biomarkers and echocardiographic predictors of myocardial dysfunction in patients with hypertension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390083/
https://www.ncbi.nlm.nih.gov/pubmed/25747153
http://dx.doi.org/10.1038/srep08916
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