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Acute ER stress regulates amyloid precursor protein processing through ubiquitin-dependent degradation

Beta-amyloid (Aβ), a major pathological hallmark of Alzheimer's disease (AD), is derived from amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase enzymes. APP is an integral membrane protein, and plays a key role in the pathogenesis of AD; however, the bio...

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Detalles Bibliográficos
Autores principales:	Jung, Eun Sun, Hong, HyunSeok, Kim, Chaeyoung, Mook-Jung, Inhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390087/ https://www.ncbi.nlm.nih.gov/pubmed/25740315 http://dx.doi.org/10.1038/srep08805

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