Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

Although mutations in several genes with diverse functions have been known to cause amyotrophic lateral sclerosis (ALS), it is unknown to what extent causal mutations impinge on common pathways that drive motor neuron (MN)-specific neurodegeneration. In this study, we combined induced pluripotent st...

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Detalles Bibliográficos
Autores principales: Bhinge, Akshay, Namboori, Seema C., Zhang, Xiaoyu, VanDongen, Antonius M.J., Stanton, Lawrence W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390134/
https://www.ncbi.nlm.nih.gov/pubmed/28366453
http://dx.doi.org/10.1016/j.stemcr.2017.02.019

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