Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein

AIM: To investigate the effects of Clostridium perfringens enterotoxin (CPE) on gastric cancer cells which highly expressed claudin-4 (CL4) protein. METHODS: In this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC79...

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Autores principales: Liang, Zheng-Yun, Kang, Xing, Chen, Hong, Wang, Meng, Guan, Wen-Xian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2017
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390300/
https://www.ncbi.nlm.nih.gov/pubmed/28451062
http://dx.doi.org/10.4251/wjgo.v9.i4.153
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author Liang, Zheng-Yun
Kang, Xing
Chen, Hong
Wang, Meng
Guan, Wen-Xian
author_facet Liang, Zheng-Yun
Kang, Xing
Chen, Hong
Wang, Meng
Guan, Wen-Xian
author_sort Liang, Zheng-Yun
collection PubMed
description AIM: To investigate the effects of Clostridium perfringens enterotoxin (CPE) on gastric cancer cells which highly expressed claudin-4 (CL4) protein. METHODS: In this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC7901 cells which highly expressed CL4 protein and the effects of CPE on subcutaneous tumor in nude mice models. RESULTS: CL4 are highly expressed in SGC7901 cells. CPE expressed significant cytotoxicity in SGC7901 cells. Suppression of CL4 expression significantly decreased CPE-mediated cytotoxicity. CPE also inhibited tumor growth in subcutaneous tumor xenograft models. CONCLUSION: CPE showed CL4 mediated cytotoxicity on gastric cancer cells SGC7901 and inhibited tumor growth in nude mice models.
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spelling pubmed-53903002017-04-28 Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein Liang, Zheng-Yun Kang, Xing Chen, Hong Wang, Meng Guan, Wen-Xian World J Gastrointest Oncol Basic Study AIM: To investigate the effects of Clostridium perfringens enterotoxin (CPE) on gastric cancer cells which highly expressed claudin-4 (CL4) protein. METHODS: In this study, we detected expression of CL4 protein in different gastric cancer cell lines. Then, we investigated the effects of CPE on SGC7901 cells which highly expressed CL4 protein and the effects of CPE on subcutaneous tumor in nude mice models. RESULTS: CL4 are highly expressed in SGC7901 cells. CPE expressed significant cytotoxicity in SGC7901 cells. Suppression of CL4 expression significantly decreased CPE-mediated cytotoxicity. CPE also inhibited tumor growth in subcutaneous tumor xenograft models. CONCLUSION: CPE showed CL4 mediated cytotoxicity on gastric cancer cells SGC7901 and inhibited tumor growth in nude mice models. Baishideng Publishing Group Inc 2017-04-15 2017-04-15 /pmc/articles/PMC5390300/ /pubmed/28451062 http://dx.doi.org/10.4251/wjgo.v9.i4.153 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Basic Study
Liang, Zheng-Yun
Kang, Xing
Chen, Hong
Wang, Meng
Guan, Wen-Xian
Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein
title Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein
title_full Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein
title_fullStr Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein
title_full_unstemmed Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein
title_short Effect of Clostridium perfringens enterotoxin on gastric cancer cells SGC7901 which highly expressed claudin-4 protein
title_sort effect of clostridium perfringens enterotoxin on gastric cancer cells sgc7901 which highly expressed claudin-4 protein
topic Basic Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390300/
https://www.ncbi.nlm.nih.gov/pubmed/28451062
http://dx.doi.org/10.4251/wjgo.v9.i4.153
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