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Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation

Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart di...

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Autores principales: Yamawaki, Yosuke, Oue, Kana, Shirawachi, Satomi, Asano, Satoshi, Harada, Kae, Kanematsu, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390332/
https://www.ncbi.nlm.nih.gov/pubmed/28408965
http://dx.doi.org/10.1016/j.jdsr.2016.06.001
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author Yamawaki, Yosuke
Oue, Kana
Shirawachi, Satomi
Asano, Satoshi
Harada, Kae
Kanematsu, Takashi
author_facet Yamawaki, Yosuke
Oue, Kana
Shirawachi, Satomi
Asano, Satoshi
Harada, Kae
Kanematsu, Takashi
author_sort Yamawaki, Yosuke
collection PubMed
description Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol. Prevention and control of obesity is complex, and requires a multifaceted approach. The elucidation of molecular mechanisms driving fat metabolism (adipogenesis and lipolysis) aims at developing clinical treatments to control obesity. We recently reported a new regulatory mechanism in fat metabolism: a protein phosphatase binding protein, phospholipase C-related catalytically inactive protein (PRIP), regulates lipolysis in white adipocytes and heat production in brown adipocytes via phosphoregulation. Deficiency of PRIP in mice led to reduced fat accumulation and increased energy expenditure, resulting in a lean phenotype. Here, we evaluate PRIP as a new therapeutic target for the control of obesity.
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spelling pubmed-53903322017-04-13 Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation Yamawaki, Yosuke Oue, Kana Shirawachi, Satomi Asano, Satoshi Harada, Kae Kanematsu, Takashi Jpn Dent Sci Rev Review Article Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol. Prevention and control of obesity is complex, and requires a multifaceted approach. The elucidation of molecular mechanisms driving fat metabolism (adipogenesis and lipolysis) aims at developing clinical treatments to control obesity. We recently reported a new regulatory mechanism in fat metabolism: a protein phosphatase binding protein, phospholipase C-related catalytically inactive protein (PRIP), regulates lipolysis in white adipocytes and heat production in brown adipocytes via phosphoregulation. Deficiency of PRIP in mice led to reduced fat accumulation and increased energy expenditure, resulting in a lean phenotype. Here, we evaluate PRIP as a new therapeutic target for the control of obesity. Elsevier 2017-02 2016-06-27 /pmc/articles/PMC5390332/ /pubmed/28408965 http://dx.doi.org/10.1016/j.jdsr.2016.06.001 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Yamawaki, Yosuke
Oue, Kana
Shirawachi, Satomi
Asano, Satoshi
Harada, Kae
Kanematsu, Takashi
Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
title Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
title_full Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
title_fullStr Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
title_full_unstemmed Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
title_short Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
title_sort phospholipase c-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390332/
https://www.ncbi.nlm.nih.gov/pubmed/28408965
http://dx.doi.org/10.1016/j.jdsr.2016.06.001
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