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Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism
Increasing recent research has sought to understand the recollection impairments experienced by individuals with autism spectrum disorder (ASD). Here, we tested whether these memory deficits reflect a reduction in the probability of retrieval success or in the precision of memory representations. We...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390398/ https://www.ncbi.nlm.nih.gov/pubmed/28057726 http://dx.doi.org/10.1093/cercor/bhw417 |
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author | Cooper, Rose A. Richter, Franziska R. Bays, Paul M. Plaisted-Grant, Kate C. Baron-Cohen, Simon Simons, Jon S. |
author_facet | Cooper, Rose A. Richter, Franziska R. Bays, Paul M. Plaisted-Grant, Kate C. Baron-Cohen, Simon Simons, Jon S. |
author_sort | Cooper, Rose A. |
collection | PubMed |
description | Increasing recent research has sought to understand the recollection impairments experienced by individuals with autism spectrum disorder (ASD). Here, we tested whether these memory deficits reflect a reduction in the probability of retrieval success or in the precision of memory representations. We also used functional magnetic resonance imaging (fMRI) to study the neural mechanisms underlying memory encoding and retrieval in ASD, focusing particularly on the functional connectivity of core episodic memory networks. Adults with ASD and typical control participants completed a memory task that involved studying visual displays and subsequently using a continuous dial to recreate their appearance. The ASD group exhibited reduced retrieval success, but there was no evidence of a difference in retrieval precision. fMRI data revealed similar patterns of brain activity and functional connectivity during memory encoding in the 2 groups, though encoding-related lateral frontal activity predicted subsequent retrieval success only in the control group. During memory retrieval, the ASD group exhibited attenuated lateral frontal activity and substantially reduced hippocampal connectivity, particularly between hippocampus and regions of the fronto-parietal control network. These findings demonstrate notable differences in brain function during episodic memory retrieval in ASD and highlight the importance of functional connectivity to understanding recollection-related retrieval deficits in this population. |
format | Online Article Text |
id | pubmed-5390398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-53903982017-04-24 Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism Cooper, Rose A. Richter, Franziska R. Bays, Paul M. Plaisted-Grant, Kate C. Baron-Cohen, Simon Simons, Jon S. Cereb Cortex Original Articles Increasing recent research has sought to understand the recollection impairments experienced by individuals with autism spectrum disorder (ASD). Here, we tested whether these memory deficits reflect a reduction in the probability of retrieval success or in the precision of memory representations. We also used functional magnetic resonance imaging (fMRI) to study the neural mechanisms underlying memory encoding and retrieval in ASD, focusing particularly on the functional connectivity of core episodic memory networks. Adults with ASD and typical control participants completed a memory task that involved studying visual displays and subsequently using a continuous dial to recreate their appearance. The ASD group exhibited reduced retrieval success, but there was no evidence of a difference in retrieval precision. fMRI data revealed similar patterns of brain activity and functional connectivity during memory encoding in the 2 groups, though encoding-related lateral frontal activity predicted subsequent retrieval success only in the control group. During memory retrieval, the ASD group exhibited attenuated lateral frontal activity and substantially reduced hippocampal connectivity, particularly between hippocampus and regions of the fronto-parietal control network. These findings demonstrate notable differences in brain function during episodic memory retrieval in ASD and highlight the importance of functional connectivity to understanding recollection-related retrieval deficits in this population. Oxford University Press 2017-02 2017-01-05 /pmc/articles/PMC5390398/ /pubmed/28057726 http://dx.doi.org/10.1093/cercor/bhw417 Text en © The Author 2017. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Cooper, Rose A. Richter, Franziska R. Bays, Paul M. Plaisted-Grant, Kate C. Baron-Cohen, Simon Simons, Jon S. Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism |
title | Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism |
title_full | Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism |
title_fullStr | Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism |
title_full_unstemmed | Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism |
title_short | Reduced Hippocampal Functional Connectivity During Episodic Memory Retrieval in Autism |
title_sort | reduced hippocampal functional connectivity during episodic memory retrieval in autism |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390398/ https://www.ncbi.nlm.nih.gov/pubmed/28057726 http://dx.doi.org/10.1093/cercor/bhw417 |
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