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Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching

BACKGROUND: Transforming growth factor β (TGF-β) signalling regulates the development of embryos and tissue homeostasis in adults. In conjunction with other oncogenic changes, long-term perturbation of TGF-β signalling is associated with cancer metastasis. Although TGF-β signalling can be complex, m...

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Detalles Bibliográficos
Autores principales:	Khatibi, Shabnam, Zhu, Hong-Jian, Wagner, John, Tan, Chin Wee, Manton, Jonathan H., Burgess, Antony W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390422/ https://www.ncbi.nlm.nih.gov/pubmed/28407804 http://dx.doi.org/10.1186/s12918-017-0421-5

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