Cargando…

A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery

Purpose. We evaluated the efficacy and safety of a mechanical device, the P-chute, in corneal endothelium preservation during phacoemulsification in a rabbit model. Methods. Twenty-four rabbits were randomly assigned into 2 groups. One eye of each rabbit underwent phacoemulsification that simulated...

Descripción completa

Detalles Bibliográficos
Autores principales: Chew, Annabel C. Y., Chan, Anita, Nongpiur, Monisha E., Peh, Gary, Barathi, Veluchamy A., Lwin, Nyein C., Ong, Charles, Perera, Shamira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390626/
https://www.ncbi.nlm.nih.gov/pubmed/28465835
http://dx.doi.org/10.1155/2017/6906139
_version_ 1782521499374059520
author Chew, Annabel C. Y.
Chan, Anita
Nongpiur, Monisha E.
Peh, Gary
Barathi, Veluchamy A.
Lwin, Nyein C.
Ong, Charles
Perera, Shamira
author_facet Chew, Annabel C. Y.
Chan, Anita
Nongpiur, Monisha E.
Peh, Gary
Barathi, Veluchamy A.
Lwin, Nyein C.
Ong, Charles
Perera, Shamira
author_sort Chew, Annabel C. Y.
collection PubMed
description Purpose. We evaluated the efficacy and safety of a mechanical device, the P-chute, in corneal endothelium preservation during phacoemulsification in a rabbit model. Methods. Twenty-four rabbits were randomly assigned into 2 groups. One eye of each rabbit underwent phacoemulsification that simulated the removal of a dense nucleus, with or without the P-chute. Serial slit-lamp examinations, anterior segment optical coherence tomography (ASOCT) scans, and specular microscopy were performed. Three rabbits from each group were sacrificed on postoperative days (PODs) 1, 5, 7, and 14. Histological analysis of the corneas was performed. Results. There was a trend towards lesser endothelial cell loss for the P-chute group at POD1 (4.9% versus 12.5%, p = 0.53), POD5 (10.4% versus 12.2%, p = 0.77), and POD7 (10.5% versus 17.2%, p = 0.52). There was no significant difference in the corneal thickness (p = >0.05) between the 2 groups. The insertion of the device was challenging. The use of the P-chute only added an extra 15% to the surgical time. Conclusions. There was a trend towards better endothelium preservation with the P-chute even though the results were not statistically significant. We believe that the device could be useful in certain surgical situations. Further work is needed to improve the device insertion.
format Online
Article
Text
id pubmed-5390626
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-53906262017-05-02 A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery Chew, Annabel C. Y. Chan, Anita Nongpiur, Monisha E. Peh, Gary Barathi, Veluchamy A. Lwin, Nyein C. Ong, Charles Perera, Shamira J Ophthalmol Research Article Purpose. We evaluated the efficacy and safety of a mechanical device, the P-chute, in corneal endothelium preservation during phacoemulsification in a rabbit model. Methods. Twenty-four rabbits were randomly assigned into 2 groups. One eye of each rabbit underwent phacoemulsification that simulated the removal of a dense nucleus, with or without the P-chute. Serial slit-lamp examinations, anterior segment optical coherence tomography (ASOCT) scans, and specular microscopy were performed. Three rabbits from each group were sacrificed on postoperative days (PODs) 1, 5, 7, and 14. Histological analysis of the corneas was performed. Results. There was a trend towards lesser endothelial cell loss for the P-chute group at POD1 (4.9% versus 12.5%, p = 0.53), POD5 (10.4% versus 12.2%, p = 0.77), and POD7 (10.5% versus 17.2%, p = 0.52). There was no significant difference in the corneal thickness (p = >0.05) between the 2 groups. The insertion of the device was challenging. The use of the P-chute only added an extra 15% to the surgical time. Conclusions. There was a trend towards better endothelium preservation with the P-chute even though the results were not statistically significant. We believe that the device could be useful in certain surgical situations. Further work is needed to improve the device insertion. Hindawi 2017 2017-03-29 /pmc/articles/PMC5390626/ /pubmed/28465835 http://dx.doi.org/10.1155/2017/6906139 Text en Copyright © 2017 Annabel C. Y. Chew et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chew, Annabel C. Y.
Chan, Anita
Nongpiur, Monisha E.
Peh, Gary
Barathi, Veluchamy A.
Lwin, Nyein C.
Ong, Charles
Perera, Shamira
A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery
title A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery
title_full A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery
title_fullStr A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery
title_full_unstemmed A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery
title_short A Rabbit Model Study to Determine the Efficacy of a Prototype Corneal Endothelium Protector during Cataract Surgery
title_sort rabbit model study to determine the efficacy of a prototype corneal endothelium protector during cataract surgery
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390626/
https://www.ncbi.nlm.nih.gov/pubmed/28465835
http://dx.doi.org/10.1155/2017/6906139
work_keys_str_mv AT chewannabelcy arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT chananita arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT nongpiurmonishae arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT pehgary arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT barathiveluchamya arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT lwinnyeinc arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT ongcharles arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT pererashamira arabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT chewannabelcy rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT chananita rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT nongpiurmonishae rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT pehgary rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT barathiveluchamya rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT lwinnyeinc rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT ongcharles rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery
AT pererashamira rabbitmodelstudytodeterminetheefficacyofaprototypecornealendotheliumprotectorduringcataractsurgery