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Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder

Social anxiety disorder (SAD) involves abnormalities in social motivation, which may be independent of well-documented differences in fear and arousal systems. Yet, the neurobiology underlying motivational difficulties in SAD is not well understood. The aim of the current study was to spatiotemporal...

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Autores principales: A. Richey, John, Ghane, Merage, Valdespino, Andrew, Coffman, Marika C., Strege, Marlene V., White, Susan W., Ollendick, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390704/
https://www.ncbi.nlm.nih.gov/pubmed/27798252
http://dx.doi.org/10.1093/scan/nsw149
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author A. Richey, John
Ghane, Merage
Valdespino, Andrew
Coffman, Marika C.
Strege, Marlene V.
White, Susan W.
Ollendick, Thomas H.
author_facet A. Richey, John
Ghane, Merage
Valdespino, Andrew
Coffman, Marika C.
Strege, Marlene V.
White, Susan W.
Ollendick, Thomas H.
author_sort A. Richey, John
collection PubMed
description Social anxiety disorder (SAD) involves abnormalities in social motivation, which may be independent of well-documented differences in fear and arousal systems. Yet, the neurobiology underlying motivational difficulties in SAD is not well understood. The aim of the current study was to spatiotemporally dissociate reward circuitry dysfunction from alterations in fear and arousal-related neural activity during anticipation and notification of social and non-social reward and punishment. During fMRI acquisition, non-depressed adults with social anxiety disorder (SAD; N = 21) and age-, sex- and IQ-matched control subjects (N = 22) completed eight runs of an incentive delay task, alternating between social and monetary outcomes and interleaved in alternating order between gain and loss outcomes. Adults with SAD demonstrated significantly reduced neural activity in ventral striatum during the anticipation of positive but not negative social outcomes. No differences between the SAD and control groups were observed during anticipation of monetary gain or loss outcomes or during anticipation of negative social images. However, consistent with previous work, the SAD group demonstrated amygdala hyper-activity upon notification of negative social outcomes. Degraded anticipatory processing in bilateral ventral striatum in SAD was constrained exclusively to anticipation of positive social information and dissociable from the effects of negative social outcomes previously observed in the amygdala. Alterations in anticipation-related neural signals may represent a promising target for treatment that is not addressed by available evidence-based interventions, which focus primarily on fear extinction and habituation processes.
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spelling pubmed-53907042017-05-01 Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder A. Richey, John Ghane, Merage Valdespino, Andrew Coffman, Marika C. Strege, Marlene V. White, Susan W. Ollendick, Thomas H. Soc Cogn Affect Neurosci Original Articles Social anxiety disorder (SAD) involves abnormalities in social motivation, which may be independent of well-documented differences in fear and arousal systems. Yet, the neurobiology underlying motivational difficulties in SAD is not well understood. The aim of the current study was to spatiotemporally dissociate reward circuitry dysfunction from alterations in fear and arousal-related neural activity during anticipation and notification of social and non-social reward and punishment. During fMRI acquisition, non-depressed adults with social anxiety disorder (SAD; N = 21) and age-, sex- and IQ-matched control subjects (N = 22) completed eight runs of an incentive delay task, alternating between social and monetary outcomes and interleaved in alternating order between gain and loss outcomes. Adults with SAD demonstrated significantly reduced neural activity in ventral striatum during the anticipation of positive but not negative social outcomes. No differences between the SAD and control groups were observed during anticipation of monetary gain or loss outcomes or during anticipation of negative social images. However, consistent with previous work, the SAD group demonstrated amygdala hyper-activity upon notification of negative social outcomes. Degraded anticipatory processing in bilateral ventral striatum in SAD was constrained exclusively to anticipation of positive social information and dissociable from the effects of negative social outcomes previously observed in the amygdala. Alterations in anticipation-related neural signals may represent a promising target for treatment that is not addressed by available evidence-based interventions, which focus primarily on fear extinction and habituation processes. Oxford University Press 2017-01 2016-10-19 /pmc/articles/PMC5390704/ /pubmed/27798252 http://dx.doi.org/10.1093/scan/nsw149 Text en © The Author(s) (2016). Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Articles
A. Richey, John
Ghane, Merage
Valdespino, Andrew
Coffman, Marika C.
Strege, Marlene V.
White, Susan W.
Ollendick, Thomas H.
Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
title Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
title_full Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
title_fullStr Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
title_full_unstemmed Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
title_short Spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
title_sort spatiotemporal dissociation of brain activity underlying threat and reward in social anxiety disorder
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390704/
https://www.ncbi.nlm.nih.gov/pubmed/27798252
http://dx.doi.org/10.1093/scan/nsw149
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