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Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?

The identification of Parrot bornaviruses (PaBV) in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease, since not all infected birds develop clinical signs. Although the most accepted theory indicates that PaBV dire...

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Autores principales: Leal de Araujo, Jeann, Tizard, Ian, Guo, Jianhua, Heatley, J Jill, Rodrigues Hoffmann, Aline, Rech, Raquel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390765/
https://www.ncbi.nlm.nih.gov/pubmed/28413724
http://dx.doi.org/10.7717/peerj.3144
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author Leal de Araujo, Jeann
Tizard, Ian
Guo, Jianhua
Heatley, J Jill
Rodrigues Hoffmann, Aline
Rech, Raquel R.
author_facet Leal de Araujo, Jeann
Tizard, Ian
Guo, Jianhua
Heatley, J Jill
Rodrigues Hoffmann, Aline
Rech, Raquel R.
author_sort Leal de Araujo, Jeann
collection PubMed
description The identification of Parrot bornaviruses (PaBV) in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease, since not all infected birds develop clinical signs. Although the most accepted theory indicates that PaBV directly triggers an inflammatory response in this disease, another hypothesis suggests the disease is triggered by autoantibodies targeting neuronal gangliosides, and PDD might therefore resemble Guillain-Barré Syndrome (GBS) in its pathogenesis. Experimental inoculation of pure gangliosides and brain-derived ganglioside extracts were used in two different immunization studies. The first study was performed on 17 healthy chickens (Gallus gallus domesticus): 11 chickens were inoculated with a brain ganglioside extract in Freund’s complete adjuvant (FCA) and six chickens inoculated with phosphate-buffered saline. A second study was performed five healthy quaker parrots (Myiopsitta monachus) that were divided into three groups: Two quaker parrots received purified gangliosides in FCA, two received a crude brain extract in FCA, and one control quaker parrot received FCA alone. One chicken developed difficult in walking. Histologically, only a mild perivascular and perineural lymphocytic infiltrate in the proventriculus. Two quaker parrots (one from each treatment group) had mild lymphoplasmacytic encephalitis and myelitis. However, none of the quaker parrots developed myenteric ganglioneuritis, suggesting that autoantibodies against gangliosides in birds are not associated with a condition resembling PDD.
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spelling pubmed-53907652017-04-14 Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds? Leal de Araujo, Jeann Tizard, Ian Guo, Jianhua Heatley, J Jill Rodrigues Hoffmann, Aline Rech, Raquel R. PeerJ Veterinary Medicine The identification of Parrot bornaviruses (PaBV) in psittacine birds with proventricular dilatation disease (PDD) has not been sufficient to explain the pathogenesis of this fatal disease, since not all infected birds develop clinical signs. Although the most accepted theory indicates that PaBV directly triggers an inflammatory response in this disease, another hypothesis suggests the disease is triggered by autoantibodies targeting neuronal gangliosides, and PDD might therefore resemble Guillain-Barré Syndrome (GBS) in its pathogenesis. Experimental inoculation of pure gangliosides and brain-derived ganglioside extracts were used in two different immunization studies. The first study was performed on 17 healthy chickens (Gallus gallus domesticus): 11 chickens were inoculated with a brain ganglioside extract in Freund’s complete adjuvant (FCA) and six chickens inoculated with phosphate-buffered saline. A second study was performed five healthy quaker parrots (Myiopsitta monachus) that were divided into three groups: Two quaker parrots received purified gangliosides in FCA, two received a crude brain extract in FCA, and one control quaker parrot received FCA alone. One chicken developed difficult in walking. Histologically, only a mild perivascular and perineural lymphocytic infiltrate in the proventriculus. Two quaker parrots (one from each treatment group) had mild lymphoplasmacytic encephalitis and myelitis. However, none of the quaker parrots developed myenteric ganglioneuritis, suggesting that autoantibodies against gangliosides in birds are not associated with a condition resembling PDD. PeerJ Inc. 2017-04-11 /pmc/articles/PMC5390765/ /pubmed/28413724 http://dx.doi.org/10.7717/peerj.3144 Text en ©2017 Leal de Araujo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Veterinary Medicine
Leal de Araujo, Jeann
Tizard, Ian
Guo, Jianhua
Heatley, J Jill
Rodrigues Hoffmann, Aline
Rech, Raquel R.
Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
title Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
title_full Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
title_fullStr Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
title_full_unstemmed Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
title_short Are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
title_sort are anti-ganglioside antibodies associated with proventricular dilatation disease in birds?
topic Veterinary Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390765/
https://www.ncbi.nlm.nih.gov/pubmed/28413724
http://dx.doi.org/10.7717/peerj.3144
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