Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor

Mostrar otras versiones (1)

Invited for this month's cover picture is the group of Professor Rainer Riedl from the Institute of Chemistry and Biotechnology at the Zurich University of Applied Sciences (ZHAW), Switzerland. The cover picture depicts the structure‐based design of a drug‐like small molecule inhibitor of matri...

Descripción completa

Detalles Bibliográficos
Autores principales: Fischer, Thomas, Riedl, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Cover Profile
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390808/
https://www.ncbi.nlm.nih.gov/pubmed/28413746
http://dx.doi.org/10.1002/open.201700042
_version_ 1782521536753696768
author Fischer, Thomas
Riedl, Rainer
author_facet Fischer, Thomas
Riedl, Rainer
author_sort Fischer, Thomas
collection PubMed
description Invited for this month's cover picture is the group of Professor Rainer Riedl from the Institute of Chemistry and Biotechnology at the Zurich University of Applied Sciences (ZHAW), Switzerland. The cover picture depicts the structure‐based design of a drug‐like small molecule inhibitor of matrix metalloproteinase‐13 (MMP‐13) with a combined dual binding motif. The targeted introduction of a single fluoro atom was of vital importance for the optimization of the inhibitor. For more details, read the full text of the Communication at 10.1002/open.201600158.
format Online
Article
Text
id pubmed-5390808
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-53908082017-04-14 Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor Fischer, Thomas Riedl, Rainer ChemistryOpen Cover Profile Invited for this month's cover picture is the group of Professor Rainer Riedl from the Institute of Chemistry and Biotechnology at the Zurich University of Applied Sciences (ZHAW), Switzerland. The cover picture depicts the structure‐based design of a drug‐like small molecule inhibitor of matrix metalloproteinase‐13 (MMP‐13) with a combined dual binding motif. The targeted introduction of a single fluoro atom was of vital importance for the optimization of the inhibitor. For more details, read the full text of the Communication at 10.1002/open.201600158. John Wiley and Sons Inc. 2017-03-13 /pmc/articles/PMC5390808/ /pubmed/28413746 http://dx.doi.org/10.1002/open.201700042 Text en © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim
spellingShingle Cover Profile
Fischer, Thomas
Riedl, Rainer
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
title Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
title_full Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
title_fullStr Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
title_full_unstemmed Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
title_short Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
title_sort targeted fluoro positioning for the discovery of a potent and highly selective matrix metalloproteinase inhibitor
topic Cover Profile
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390808/
https://www.ncbi.nlm.nih.gov/pubmed/28413746
http://dx.doi.org/10.1002/open.201700042
work_keys_str_mv AT fischerthomas targetedfluoropositioningforthediscoveryofapotentandhighlyselectivematrixmetalloproteinaseinhibitor
AT riedlrainer targetedfluoropositioningforthediscoveryofapotentandhighlyselectivematrixmetalloproteinaseinhibitor

Ejemplares similares