Cargando…

Quantitative T2 mapping of white matter: applications for ageing and cognitive decline

In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provided by diffusion tensor imaging (DTI) in ageing of h...

Descripción completa

Detalles Bibliográficos
Autores principales: Knight, Michael J, McCann, Bryony, Tsivos, Demitra, Dillon, Serena, Coulthard, Elizabeth, Kauppinen, Risto A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOP Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390949/
https://www.ncbi.nlm.nih.gov/pubmed/27384985
http://dx.doi.org/10.1088/0031-9155/61/15/5587
_version_ 1782521553061150720
author Knight, Michael J
McCann, Bryony
Tsivos, Demitra
Dillon, Serena
Coulthard, Elizabeth
Kauppinen, Risto A
author_facet Knight, Michael J
McCann, Bryony
Tsivos, Demitra
Dillon, Serena
Coulthard, Elizabeth
Kauppinen, Risto A
author_sort Knight, Michael J
collection PubMed
description In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provided by diffusion tensor imaging (DTI) in ageing of healthy controls (HC), Alzheimer’s disease (AD) and mild cognitive impairment (MCI). T2 and diffusion MRI metrics were quantified in HC and patients with MCI and mild AD using multi-echo MRI and DTI. We used tract-based spatial statistics (TBSS) to evaluate quantitative MRI parameters in white matter (WM). A prolonged T2 in WM was associated with AD, and able to distinguish AD from MCI, and AD from HC. Shorter WM T2 was associated with better cognition and younger age in general. In no case was a reduction in T2 associated with poorer cognition. We also applied principal component analysis, showing that WM volume changes independently of  T2, MRI diffusion indices and cognitive performance indices. Our data add to the evidence that age-related and AD-related decline in cognition is in part attributable to WM tissue state, and much less to WM quantity. These observations suggest that WM is involved in AD pathology, and that T2 relaxometry is a potential imaging modality for detecting and characterising WM in cognitive decline and dementia.
format Online
Article
Text
id pubmed-5390949
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher IOP Publishing
record_format MEDLINE/PubMed
spelling pubmed-53909492017-04-27 Quantitative T2 mapping of white matter: applications for ageing and cognitive decline Knight, Michael J McCann, Bryony Tsivos, Demitra Dillon, Serena Coulthard, Elizabeth Kauppinen, Risto A Phys Med Biol Paper In MRI, the coherence lifetime T2 is sensitive to the magnetic environment imposed by tissue microstructure and biochemistry in vivo. Here we explore the possibility that the use of T2 relaxometry may provide information complementary to that provided by diffusion tensor imaging (DTI) in ageing of healthy controls (HC), Alzheimer’s disease (AD) and mild cognitive impairment (MCI). T2 and diffusion MRI metrics were quantified in HC and patients with MCI and mild AD using multi-echo MRI and DTI. We used tract-based spatial statistics (TBSS) to evaluate quantitative MRI parameters in white matter (WM). A prolonged T2 in WM was associated with AD, and able to distinguish AD from MCI, and AD from HC. Shorter WM T2 was associated with better cognition and younger age in general. In no case was a reduction in T2 associated with poorer cognition. We also applied principal component analysis, showing that WM volume changes independently of  T2, MRI diffusion indices and cognitive performance indices. Our data add to the evidence that age-related and AD-related decline in cognition is in part attributable to WM tissue state, and much less to WM quantity. These observations suggest that WM is involved in AD pathology, and that T2 relaxometry is a potential imaging modality for detecting and characterising WM in cognitive decline and dementia. IOP Publishing 2016-08-07 2016-07-06 /pmc/articles/PMC5390949/ /pubmed/27384985 http://dx.doi.org/10.1088/0031-9155/61/15/5587 Text en © 2016 Institute of Physics and Engineering in Medicine http://creativecommons.org/licenses/by/3.0/ Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0) . Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
spellingShingle Paper
Knight, Michael J
McCann, Bryony
Tsivos, Demitra
Dillon, Serena
Coulthard, Elizabeth
Kauppinen, Risto A
Quantitative T2 mapping of white matter: applications for ageing and cognitive decline
title Quantitative T2 mapping of white matter: applications for ageing and cognitive decline
title_full Quantitative T2 mapping of white matter: applications for ageing and cognitive decline
title_fullStr Quantitative T2 mapping of white matter: applications for ageing and cognitive decline
title_full_unstemmed Quantitative T2 mapping of white matter: applications for ageing and cognitive decline
title_short Quantitative T2 mapping of white matter: applications for ageing and cognitive decline
title_sort quantitative t2 mapping of white matter: applications for ageing and cognitive decline
topic Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390949/
https://www.ncbi.nlm.nih.gov/pubmed/27384985
http://dx.doi.org/10.1088/0031-9155/61/15/5587
work_keys_str_mv AT knightmichaelj quantitativet2mappingofwhitematterapplicationsforageingandcognitivedecline
AT mccannbryony quantitativet2mappingofwhitematterapplicationsforageingandcognitivedecline
AT tsivosdemitra quantitativet2mappingofwhitematterapplicationsforageingandcognitivedecline
AT dillonserena quantitativet2mappingofwhitematterapplicationsforageingandcognitivedecline
AT coulthardelizabeth quantitativet2mappingofwhitematterapplicationsforageingandcognitivedecline
AT kauppinenristoa quantitativet2mappingofwhitematterapplicationsforageingandcognitivedecline