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Pharmacogenetic variants in TPMT alter cellular responses to cisplatin in inner ear cell lines

Cisplatin is a highly-effective and widely-used chemotherapeutic agent that causes ototoxicity in many patients. Pharmacogenomic studies of key genes controlling drug biotransformation identified variants in thiopurine methyltransferase (TPMT) as predictors of cisplatin-induced ototoxicity, although...

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Detalles Bibliográficos
Autores principales:	Bhavsar, Amit P., Gunaretnam, Erandika P., Li, Yuling, Hasbullah, Jafar S., Carleton, Bruce C., Ross, Colin J. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391095/ https://www.ncbi.nlm.nih.gov/pubmed/28406961 http://dx.doi.org/10.1371/journal.pone.0175711

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