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Cysteine residues in a yeast viral A/B toxin crucially control host cell killing via pH-triggered disulfide rearrangements

K28 is a viral A/B protein toxin that intoxicates yeast and fungal cells by endocytosis and retrograde transport to the endoplasmic reticulum (ER). Although toxin translocation into the cytosol occurs on the oxidized α/β heterodimer, the precise mechanism of how the toxin crosses the ER membrane is...

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Detalles Bibliográficos
Autores principales:	Suzuki, Yutaka, Schwartz, Sara L., Mueller, Nina C., Schmitt, Manfred J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391188/ https://www.ncbi.nlm.nih.gov/pubmed/28228551 http://dx.doi.org/10.1091/mbc.E16-12-0842

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