Cargando…
The novel mitochondrial matrix protease Ste23 is required for efficient presequence degradation and processing
Approximately 70% of mitochondrial precursor proteins are imported from the cytosol via N-terminal presequences, which are cleaved upon exposure to the mitochondrial processing protease MPP in the matrix. Cleaved presequence peptides then need to be efficiently degraded, and impairment of this clear...
Autores principales: | Taskin, Asli Aras, Kücükköse, Cansu, Burger, Nils, Mossmann, Dirk, Meisinger, Chris, Vögtle, F.-Nora |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391191/ https://www.ncbi.nlm.nih.gov/pubmed/28228553 http://dx.doi.org/10.1091/mbc.E16-10-0732 |
Ejemplares similares
-
Landscape of submitochondrial protein distribution
por: Vögtle, F.-Nora, et al.
Publicado: (2017) -
Author's View: a nuclear transcription factor relocalizing to mitochondria rescues cells from proteotoxic aggregates
por: Taskin, Asli Aras, et al.
Publicado: (2019) -
An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates
por: Poveda-Huertes, Daniel, et al.
Publicado: (2020) -
Structural basis for the mechanisms of human presequence protease conformational switch and substrate recognition
por: Liang, Wenguang G., et al.
Publicado: (2022) -
ROMO1 is a constituent of the human presequence translocase required for YME1L protease import
por: Richter, Frank, et al.
Publicado: (2019)