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Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine
Personalized and precision vaccination requires consideration of an individual’s sex and age. This article proposed systematic methods to study individual differences in adverse reactions following vaccination and chose trivalent influenza vaccine as a use case. Data were extracted from the Vaccine...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391193/ https://www.ncbi.nlm.nih.gov/pubmed/28469434 http://dx.doi.org/10.1177/1178222617700627 |
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author | Du, Jingcheng Cai, Yi Chen, Yong He, Yongqun Tao, Cui |
author_facet | Du, Jingcheng Cai, Yi Chen, Yong He, Yongqun Tao, Cui |
author_sort | Du, Jingcheng |
collection | PubMed |
description | Personalized and precision vaccination requires consideration of an individual’s sex and age. This article proposed systematic methods to study individual differences in adverse reactions following vaccination and chose trivalent influenza vaccine as a use case. Data were extracted from the Vaccine Adverse Event Reporting System from years 1990 to 2014. We first grouped symptoms into the Medical Dictionary for Regulatory Activities System Organ Classes (SOCs). We then applied zero-truncated Poisson regression and logistic regression to identify reporting differences among different individual groups over the SOCs. After that, we further studied detailed symptoms of 4 selected SOCs. In all, 19 of the 26 SOCs and 17 of the 434 symptoms under the 4 selected SOCs show significant reporting differences based on sex and/or age. In addition to detecting previously reported associations among sex, age group, and symptoms, our approach also enabled the detection of new associations. |
format | Online Article Text |
id | pubmed-5391193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-53911932017-05-03 Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine Du, Jingcheng Cai, Yi Chen, Yong He, Yongqun Tao, Cui Biomed Inform Insights Original Research Personalized and precision vaccination requires consideration of an individual’s sex and age. This article proposed systematic methods to study individual differences in adverse reactions following vaccination and chose trivalent influenza vaccine as a use case. Data were extracted from the Vaccine Adverse Event Reporting System from years 1990 to 2014. We first grouped symptoms into the Medical Dictionary for Regulatory Activities System Organ Classes (SOCs). We then applied zero-truncated Poisson regression and logistic regression to identify reporting differences among different individual groups over the SOCs. After that, we further studied detailed symptoms of 4 selected SOCs. In all, 19 of the 26 SOCs and 17 of the 434 symptoms under the 4 selected SOCs show significant reporting differences based on sex and/or age. In addition to detecting previously reported associations among sex, age group, and symptoms, our approach also enabled the detection of new associations. SAGE Publications 2017-04-11 /pmc/articles/PMC5391193/ /pubmed/28469434 http://dx.doi.org/10.1177/1178222617700627 Text en © The Author(s) 2017 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Du, Jingcheng Cai, Yi Chen, Yong He, Yongqun Tao, Cui Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine |
title | Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine |
title_full | Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine |
title_fullStr | Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine |
title_full_unstemmed | Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine |
title_short | Analysis of Individual Differences in Vaccine Pharmacovigilance Using VAERS Data and MedDRA System Organ Classes: A Use Case Study With Trivalent Influenza Vaccine |
title_sort | analysis of individual differences in vaccine pharmacovigilance using vaers data and meddra system organ classes: a use case study with trivalent influenza vaccine |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391193/ https://www.ncbi.nlm.nih.gov/pubmed/28469434 http://dx.doi.org/10.1177/1178222617700627 |
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