Cargando…

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1α prolyl hydroxylation by regulating cellular iron levels

Hypoxia Inducible transcription Factors (HIFs) are principally regulated by the 2-oxoglutarate and Iron(II) prolyl hydroxylase (PHD) enzymes, which hydroxylate the HIFα subunit, facilitating its proteasome-mediated degradation. Observations that HIFα hydroxylation can be impaired even when oxygen is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miles, Anna L, Burr, Stephen P, Grice, Guinevere L, Nathan, James A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391204/ https://www.ncbi.nlm.nih.gov/pubmed/28296633 http://dx.doi.org/10.7554/eLife.22693

Ejemplares similares

Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115
por: Larsen, Lars E., et al.
Publicado: (2021)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
por: Cockman, Matthew E, et al.
Publicado: (2019)

TMEM65 is a mitochondrial inner-membrane protein
por: Nishimura, Naotaka, et al.
Publicado: (2014)

Role of prolyl hydroxylation in the molecular interactions of collagens
por: Rappu, Pekka, et al.
Publicado: (2019)

DNA polymerase V activity is autoregulated by a novel intrinsic DNA-dependent ATPase
por: Erdem, Aysen L, et al.
Publicado: (2014)

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity
por: Tien, Jason, et al.
Publicado: (2014)

The ATPases of cohesin interface with regulators to modulate cohesin-mediated DNA tethering
por: Çamdere, Gamze, et al.
Publicado: (2015)

Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues
por: Homan, Erica P., et al.
Publicado: (2014)

EGL-9 Controls C. elegans Host Defense Specificity through Prolyl Hydroxylation-Dependent and -Independent HIF-1 Pathways
por: Luhachack, Lyly G., et al.
Publicado: (2012)

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase
por: Monroe, Nicole, et al.
Publicado: (2017)

Role of the vacuolar ATPase in the Alphavirus replication cycle
por: Schuchman, Ryan M., et al.
Publicado: (2018)

DZNep, an inhibitor of the histone methyltransferase EZH2, suppresses hepatic fibrosis through regulating miR-199a-5p/SOCS7 pathway
por: Ding, Rongrong, et al.
Publicado: (2021)

A putative ATPase mediates RNA transcription and capping in a dsRNA virus
por: Yu, Xuekui, et al.
Publicado: (2015)

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome
por: Costa, Alessandro, et al.
Publicado: (2014)

ATPase activity of the DEAD-box protein Dhh1 controls processing body formation
por: Mugler, Christopher Frederick, et al.
Publicado: (2016)

HIF1α is dispensable for oocyte development and female fertility in mice
por: Chen, Yujia, et al.
Publicado: (2022)

Identification of CCDC115 as an adverse prognostic biomarker in liver cancer based on bioinformatics and experimental analyses
por: Su, Chang, et al.
Publicado: (2023)

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching
por: Ye, Qiaozhen, et al.
Publicado: (2015)

Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1
por: Ren, Yi, et al.
Publicado: (2017)

Engineering a light-controlled F(1) ATPase using structure-based protein design
por: Hoersch, Daniel
Publicado: (2016)

Cryo-EM studies of the structure and dynamics of vacuolar-type ATPases
por: Mazhab-Jafari, Mohammad T., et al.
Publicado: (2016)

EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1α is repressed by SET7-catalyzed lysine methylation
por: Tang, Jinhua, et al.
Publicado: (2022)

The role of HIF prolyl hydroxylases in tumour growth
por: Jokilehto, Terhi, et al.
Publicado: (2010)

A gene responsible for prolyl-hydroxylation of moss-produced recombinant human erythropoietin
por: Parsons, Juliana, et al.
Publicado: (2013)

Flexibility within the Rotor and Stators of the Vacuolar H(+)-ATPase
por: Song, Chun Feng, et al.
Publicado: (2013)

Rotating with the brakes on and other unresolved features of the vacuolar ATPase
por: Rawson, Shaun, et al.
Publicado: (2016)

The curious case of vacuolar ATPase: regulation of signaling pathways
por: Pamarthy, Sahithi, et al.
Publicado: (2018)

The helical domain of the EcoR124I motor subunit participates in ATPase activity and dsDNA translocation
por: Bialevich, Vitali, et al.
Publicado: (2017)

Correction: Differential Effects of Collagen Prolyl 3-Hydroxylation on Skeletal Tissues
Publicado: (2014)

Calotropin and corotoxigenin 3-O-glucopyranoside from the desert milkweed Asclepias subulata inhibit the Na(+)/K(+)-ATPase activity
por: Meneses-Sagrero, Salvador E., et al.
Publicado: (2022)

Advances in targeting the vacuolar proton-translocating ATPase (V-ATPase) for anti-fungal therapy
por: Hayek, Summer R., et al.
Publicado: (2014)

TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport
por: Ong, Yan Shan, et al.
Publicado: (2014)

Computer modelling reveals new conformers of the ATP binding loop of Na(+)/K(+)-ATPase involved in the transphosphorylation process of the sodium pump
por: Tejral, Gracian, et al.
Publicado: (2017)

Characterization of the ATPase FlaI of the motor complex of the Pyrococcus furiosus archaellum and its interactions between the ATP-binding protein FlaH
por: Chaudhury, Paushali, et al.
Publicado: (2018)

An isoform of the vacuolar (H(+))-ATPase accessory subunit Ac45
por: Jansen, Eric J. R., et al.
Publicado: (2009)

The vacuolar H+ ATPase is a novel therapeutic target for glioblastoma
por: Di Cristofori, Andrea, et al.
Publicado: (2015)

Vacuolar-type ATPase: A proton pump to lysosomal trafficking
por: FUTAI, Masamitsu, et al.
Publicado: (2019)

RNA Interference of Genes Encoding the Vacuolar-ATPase in Liriomyza trifolii
por: Chang, Ya-Wen, et al.
Publicado: (2021)

PHD3-mediated prolyl hydroxylation of nonmuscle actin impairs polymerization and cell motility
por: Luo, Weibo, et al.
Publicado: (2014)

The vacuolar-ATPase (V-ATPase) modulates matrix metalloproteinase (MMP) isoforms in human pancreatic cancer
por: Chung, Chuhan, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_j5jlb3o5qo0t78mhr44etnb4i0