An epigenetic aging clock for dogs and wolves

Several articles describe highly accurate age estimation methods based on human DNA-methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA-met...

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Autores principales: Thompson, Michael J., vonHoldt, Bridgett, Horvath, Steve, Pellegrini, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391218/
https://www.ncbi.nlm.nih.gov/pubmed/28373601
http://dx.doi.org/10.18632/aging.101211
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author Thompson, Michael J.
vonHoldt, Bridgett
Horvath, Steve
Pellegrini, Matteo
author_facet Thompson, Michael J.
vonHoldt, Bridgett
Horvath, Steve
Pellegrini, Matteo
author_sort Thompson, Michael J.
collection PubMed
description Several articles describe highly accurate age estimation methods based on human DNA-methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA-methylation data from 46 domesticated dogs (Canis familiaris) and 62 wild gray wolves (C. lupus). By regressing chronological dog age on the resulting CpGs, we defined highly accurate multivariate age estimators for dogs (based on 41 CpGs), wolves (67 CpGs), and both combined (115 CpGs). Age related DNA methylation changes in canids implicate similar gene ontology categories as those observed in humans suggesting an evolutionarily conserved mechanism underlying age-related DNA methylation in mammals.
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spelling pubmed-53912182017-04-20 An epigenetic aging clock for dogs and wolves Thompson, Michael J. vonHoldt, Bridgett Horvath, Steve Pellegrini, Matteo Aging (Albany NY) Research Paper Several articles describe highly accurate age estimation methods based on human DNA-methylation data. It is not yet known whether similar epigenetic aging clocks can be developed based on blood methylation data from canids. Using Reduced Representation Bisulfite Sequencing, we assessed blood DNA-methylation data from 46 domesticated dogs (Canis familiaris) and 62 wild gray wolves (C. lupus). By regressing chronological dog age on the resulting CpGs, we defined highly accurate multivariate age estimators for dogs (based on 41 CpGs), wolves (67 CpGs), and both combined (115 CpGs). Age related DNA methylation changes in canids implicate similar gene ontology categories as those observed in humans suggesting an evolutionarily conserved mechanism underlying age-related DNA methylation in mammals. Impact Journals LLC 2017-03-26 /pmc/articles/PMC5391218/ /pubmed/28373601 http://dx.doi.org/10.18632/aging.101211 Text en Copyright: © 2017 Thompson et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Thompson, Michael J.
vonHoldt, Bridgett
Horvath, Steve
Pellegrini, Matteo
An epigenetic aging clock for dogs and wolves
title An epigenetic aging clock for dogs and wolves
title_full An epigenetic aging clock for dogs and wolves
title_fullStr An epigenetic aging clock for dogs and wolves
title_full_unstemmed An epigenetic aging clock for dogs and wolves
title_short An epigenetic aging clock for dogs and wolves
title_sort epigenetic aging clock for dogs and wolves
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391218/
https://www.ncbi.nlm.nih.gov/pubmed/28373601
http://dx.doi.org/10.18632/aging.101211
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