In silico design of novel probes for the atypical opioid receptor MRGPRX2

The primate-exclusive MRGPRX2 G protein-coupled receptor (GPCR) has been suggested to modulate pain and itch. Despite putative peptide and small molecule MRGPRX2 agonists, selective nanomolar potency probes have not yet been reported. To identify a MRGPRX2 probe, we first screened 5,695 small molecu...

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Detalles Bibliográficos
Autores principales: Lansu, Katherine, Karpiak, Joel, Liu, Jing, Huang, Xi-Ping, McCorvy, John D., Kroeze, Wesley K., Che, Tao, Nagase, Hiroshi, Carroll, Frank I., Jin, Jian, Shoichet, Brian K., Roth, Bryan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391270/
https://www.ncbi.nlm.nih.gov/pubmed/28288109
http://dx.doi.org/10.1038/nchembio.2334

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