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Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan

Chromatin and metabolic states both influence lifespan, but how they interact in lifespan regulation is largely unknown. The COMPASS chromatin complex, which trimethylates lysine 4 on histone H3 (H3K4me3), regulates lifespan in C. elegans. However, the mechanism by which H3K4me3 modifiers impact lon...

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Detalles Bibliográficos
Autores principales:	Han, Shuo, Schroeder, Elizabeth A., Silva-García, Carlos G., Hebestreit, Katja, Mair, William B., Brunet, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391274/ https://www.ncbi.nlm.nih.gov/pubmed/28379943 http://dx.doi.org/10.1038/nature21686

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