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Review: Immunology of sinusitis, trauma, asthma, and sepsis
BACKGROUND: This review article is important for allergists/immunologists and otolaryngologists. It discussed chronic rhinosinusitis, epidemiology, pathogenesis, innate adaptive immunology, nuclear factor–kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma, sinusitis...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
OceanSide Publications, Inc.
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391492/ https://www.ncbi.nlm.nih.gov/pubmed/26686215 http://dx.doi.org/10.2500/ar.2015.6.0140 |
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author | Frieri, Marianne Kumar, Krishan Boutin, Anthony |
author_facet | Frieri, Marianne Kumar, Krishan Boutin, Anthony |
author_sort | Frieri, Marianne |
collection | PubMed |
description | BACKGROUND: This review article is important for allergists/immunologists and otolaryngologists. It discussed chronic rhinosinusitis, epidemiology, pathogenesis, innate adaptive immunology, nuclear factor–kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma, sinusitis, elderly pathogenesis, oxidative stress, depression, seasonal variation, vitamin D, genetic susceptibility and sepsis, hereditary angioedema related to trauma and stress. OBJECTIVE: The objective of this review is to link chronic rhinosinusitis, epidemiology, innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma and sinusitis. METHODS: A literature search was conducted from several articles, prospective studies, recent reviews and earlier reports. A synergistic relationship develops between activation of the innate immune system and the loss of organ barrier functions. Many complex factors, such as genetics, physical agents, mediators in the development of organ failure both in asthma, sinusitis, stress, depression and trauma, leading to posttraumatic organ failure. Asthma and sepsis, a common condition encountered in hospital environments remains an important cause of death at intensive care units where allergists/immunologists and otolaryngologists are frequently consulted. The patient's immune surveillance could fail to eliminate the pathogen, allowing it to spread and there is a proinflammatory mediator release with inappropriate activation. CONCLUSION: This review discussed chronic rhinosinusitis, sinusitis related to trauma, the innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, inflammation, reactive oxygen species, asthma pathogenesis, and asthma in the elderly, oxidative stress, depression, seasonal variation and vitamin D, cytokines, genetic susceptibility related to sepsis, hereditary angioedema related to trauma and stress. |
format | Online Article Text |
id | pubmed-5391492 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | OceanSide Publications, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53914922017-04-17 Review: Immunology of sinusitis, trauma, asthma, and sepsis Frieri, Marianne Kumar, Krishan Boutin, Anthony Allergy Rhinol (Providence) Articles BACKGROUND: This review article is important for allergists/immunologists and otolaryngologists. It discussed chronic rhinosinusitis, epidemiology, pathogenesis, innate adaptive immunology, nuclear factor–kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma, sinusitis, elderly pathogenesis, oxidative stress, depression, seasonal variation, vitamin D, genetic susceptibility and sepsis, hereditary angioedema related to trauma and stress. OBJECTIVE: The objective of this review is to link chronic rhinosinusitis, epidemiology, innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, reactive oxygen species, asthma and sinusitis. METHODS: A literature search was conducted from several articles, prospective studies, recent reviews and earlier reports. A synergistic relationship develops between activation of the innate immune system and the loss of organ barrier functions. Many complex factors, such as genetics, physical agents, mediators in the development of organ failure both in asthma, sinusitis, stress, depression and trauma, leading to posttraumatic organ failure. Asthma and sepsis, a common condition encountered in hospital environments remains an important cause of death at intensive care units where allergists/immunologists and otolaryngologists are frequently consulted. The patient's immune surveillance could fail to eliminate the pathogen, allowing it to spread and there is a proinflammatory mediator release with inappropriate activation. CONCLUSION: This review discussed chronic rhinosinusitis, sinusitis related to trauma, the innate and adaptive immunology, NF-kappa B related to inflammation, sepsis, complement, inflammation, reactive oxygen species, asthma pathogenesis, and asthma in the elderly, oxidative stress, depression, seasonal variation and vitamin D, cytokines, genetic susceptibility related to sepsis, hereditary angioedema related to trauma and stress. OceanSide Publications, Inc. 2015 /pmc/articles/PMC5391492/ /pubmed/26686215 http://dx.doi.org/10.2500/ar.2015.6.0140 Text en Copyright © 2015, OceanSide Publications, Inc., U.S.A. This work is published and licensed by OceanSide Publications, Inc. The full terms of this license are available at https://www.allergyandrhinology.com/terms and incorporate the Creative Commons License Deed: (Attribution – Non-Commercial – NoDerivs 4.0 Unported (CC BY-NC-ND 4.0). By accessing the work you hereby accept the terms. Non-commercial uses of the work are permitted without any further permission from OceanSide Publications, Inc., provided the work is properly attributed. Any use of the work other then as authorized under this license or copyright law is prohibited. |
spellingShingle | Articles Frieri, Marianne Kumar, Krishan Boutin, Anthony Review: Immunology of sinusitis, trauma, asthma, and sepsis |
title | Review: Immunology of sinusitis, trauma, asthma, and sepsis |
title_full | Review: Immunology of sinusitis, trauma, asthma, and sepsis |
title_fullStr | Review: Immunology of sinusitis, trauma, asthma, and sepsis |
title_full_unstemmed | Review: Immunology of sinusitis, trauma, asthma, and sepsis |
title_short | Review: Immunology of sinusitis, trauma, asthma, and sepsis |
title_sort | review: immunology of sinusitis, trauma, asthma, and sepsis |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391492/ https://www.ncbi.nlm.nih.gov/pubmed/26686215 http://dx.doi.org/10.2500/ar.2015.6.0140 |
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