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Microsatellite Instability in Medullary Carcinoma of the Colon
Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called micros...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Publications, Pavia, Italy
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391516/ https://www.ncbi.nlm.nih.gov/pubmed/28458789 http://dx.doi.org/10.4081/rt.2017.6541 |
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author | Martinotti, Mario Cirillo, Fernando Ungari, Marco Tanzi, Giulia Rolando, Giovanni Tarasconi, Antonio Ranieri, Valerio Aulisa, Paolo Vismarra, Marco Rovatti, Massimo Trombatore, Monica |
author_facet | Martinotti, Mario Cirillo, Fernando Ungari, Marco Tanzi, Giulia Rolando, Giovanni Tarasconi, Antonio Ranieri, Valerio Aulisa, Paolo Vismarra, Marco Rovatti, Massimo Trombatore, Monica |
author_sort | Martinotti, Mario |
collection | PubMed |
description | Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called microsatellite instability (MSI). We present the case of a 44 years old Caucasian woman, who referred to the Emergency Room with symptoms mimicking an acute appendicitis. Computed tomography and colonoscopy demonstrated an ulcerated and stenotic lesion of the caecum without signs of metastasis and peritoneal carcinosis. Patient underwent a laparoscopic right colectomy. The final pathologic findings provided the diagnosis of medullary carcinoma with MSI. Patient then underwent adjuvant chemotherapy according to the FOLFOX-4 protocol (association of 5-Fluorouracil, Leucovorin, and Oxaliplatin) for twelve cycles. At two-years follow-up, patient is disease free. MC in association with MSI is a non-frequent tumor of the colon characterized by a better prognosis compared to other types of poorly differentiated adenocarcinoma. In the observed case, 24 months after the surgical operation, the patient is in good health and there is no evidence of metastasis or relapse. |
format | Online Article Text |
id | pubmed-5391516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-53915162017-04-28 Microsatellite Instability in Medullary Carcinoma of the Colon Martinotti, Mario Cirillo, Fernando Ungari, Marco Tanzi, Giulia Rolando, Giovanni Tarasconi, Antonio Ranieri, Valerio Aulisa, Paolo Vismarra, Marco Rovatti, Massimo Trombatore, Monica Rare Tumors Case Report Medullary carcinoma (MC) of the large intestine is a relatively new histological type of adenocarcinoma characterized by poor glandular differentiation and an intraepithelial lymphocytic infiltrate. MC can be associated to a defective mechanism for DNA mismatch repair, caused by the so-called microsatellite instability (MSI). We present the case of a 44 years old Caucasian woman, who referred to the Emergency Room with symptoms mimicking an acute appendicitis. Computed tomography and colonoscopy demonstrated an ulcerated and stenotic lesion of the caecum without signs of metastasis and peritoneal carcinosis. Patient underwent a laparoscopic right colectomy. The final pathologic findings provided the diagnosis of medullary carcinoma with MSI. Patient then underwent adjuvant chemotherapy according to the FOLFOX-4 protocol (association of 5-Fluorouracil, Leucovorin, and Oxaliplatin) for twelve cycles. At two-years follow-up, patient is disease free. MC in association with MSI is a non-frequent tumor of the colon characterized by a better prognosis compared to other types of poorly differentiated adenocarcinoma. In the observed case, 24 months after the surgical operation, the patient is in good health and there is no evidence of metastasis or relapse. PAGEPress Publications, Pavia, Italy 2017-03-30 /pmc/articles/PMC5391516/ /pubmed/28458789 http://dx.doi.org/10.4081/rt.2017.6541 Text en ©Copyright M. Martinotti et al., 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Martinotti, Mario Cirillo, Fernando Ungari, Marco Tanzi, Giulia Rolando, Giovanni Tarasconi, Antonio Ranieri, Valerio Aulisa, Paolo Vismarra, Marco Rovatti, Massimo Trombatore, Monica Microsatellite Instability in Medullary Carcinoma of the Colon |
title | Microsatellite Instability in Medullary Carcinoma of the Colon |
title_full | Microsatellite Instability in Medullary Carcinoma of the Colon |
title_fullStr | Microsatellite Instability in Medullary Carcinoma of the Colon |
title_full_unstemmed | Microsatellite Instability in Medullary Carcinoma of the Colon |
title_short | Microsatellite Instability in Medullary Carcinoma of the Colon |
title_sort | microsatellite instability in medullary carcinoma of the colon |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391516/ https://www.ncbi.nlm.nih.gov/pubmed/28458789 http://dx.doi.org/10.4081/rt.2017.6541 |
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