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The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited

Studies carried out during the past 45 years on the effects of chronic low-frequency stimulation on skeletal muscle have revealed a multiplicity of adaptive changes of muscle fibres in response to increased activity. As reflected by induced changes in the metabolic properties, protein profiles of th...

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Detalles Bibliográficos
Autores principales: Pette, Dirk, Vrbová, Gerta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391529/
https://www.ncbi.nlm.nih.gov/pubmed/28458806
http://dx.doi.org/10.4081/ejtm.2017.6368
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author Pette, Dirk
Vrbová, Gerta
author_facet Pette, Dirk
Vrbová, Gerta
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description Studies carried out during the past 45 years on the effects of chronic low-frequency stimulation on skeletal muscle have revealed a multiplicity of adaptive changes of muscle fibres in response to increased activity. As reflected by induced changes in the metabolic properties, protein profiles of the contractile machinery and elements of the Ca(2+)-regulatory system, all essential components of the muscle fibre undergo pronounced changes in their properties that ultimately lead to their reversible transformation from fast-to-slow phenotype. The chronic low-frequency stimulation experiment thus allows exploring many aspects of the plasticity of mammalian skeletal muscle. Moreover it offers the possibility of elucidating molecular mechanisms that remodel phenotypic properties of a differentiated post-mitotic cell during adaptation to altered functional demands. The understanding of the adaptive potential of muscle can be taken advantage of for repairing muscle damage in various muscle diseases. In addition it can be used to prevent muscle wasting during inactivity and aging. Indeed, pioneering studies are still the sound grounds for the many current applications of Functional Electrical Stimulation and for the related research activities that are still proposed and funded.
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spelling pubmed-53915292017-04-28 The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited Pette, Dirk Vrbová, Gerta Eur J Transl Myol Reviews Studies carried out during the past 45 years on the effects of chronic low-frequency stimulation on skeletal muscle have revealed a multiplicity of adaptive changes of muscle fibres in response to increased activity. As reflected by induced changes in the metabolic properties, protein profiles of the contractile machinery and elements of the Ca(2+)-regulatory system, all essential components of the muscle fibre undergo pronounced changes in their properties that ultimately lead to their reversible transformation from fast-to-slow phenotype. The chronic low-frequency stimulation experiment thus allows exploring many aspects of the plasticity of mammalian skeletal muscle. Moreover it offers the possibility of elucidating molecular mechanisms that remodel phenotypic properties of a differentiated post-mitotic cell during adaptation to altered functional demands. The understanding of the adaptive potential of muscle can be taken advantage of for repairing muscle damage in various muscle diseases. In addition it can be used to prevent muscle wasting during inactivity and aging. Indeed, pioneering studies are still the sound grounds for the many current applications of Functional Electrical Stimulation and for the related research activities that are still proposed and funded. PAGEPress Publications, Pavia, Italy 2017-02-24 /pmc/articles/PMC5391529/ /pubmed/28458806 http://dx.doi.org/10.4081/ejtm.2017.6368 Text en http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License (by-nc 4.0) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Reviews
Pette, Dirk
Vrbová, Gerta
The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited
title The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited
title_full The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited
title_fullStr The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited
title_full_unstemmed The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited
title_short The Contribution of Neuromuscular Stimulation in Elucidating Muscle Plasticity Revisited
title_sort contribution of neuromuscular stimulation in elucidating muscle plasticity revisited
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391529/
https://www.ncbi.nlm.nih.gov/pubmed/28458806
http://dx.doi.org/10.4081/ejtm.2017.6368
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