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Resveratrol regulates body weight in healthy and ovariectomized rats

OBJECTIVE: The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of the study was to explore the effects of RES on the body weight of ovariectomized...

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Autores principales: Sharma, Rupali, Sharma, Neel Kamal, Thungapathra, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391549/
https://www.ncbi.nlm.nih.gov/pubmed/28413432
http://dx.doi.org/10.1186/s12986-017-0183-5
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author Sharma, Rupali
Sharma, Neel Kamal
Thungapathra, M.
author_facet Sharma, Rupali
Sharma, Neel Kamal
Thungapathra, M.
author_sort Sharma, Rupali
collection PubMed
description OBJECTIVE: The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of the study was to explore the effects of RES on the body weight of ovariectomized (OVX) female rats with controls and to relate their biochemical parameters. METHODS: Female Wistar rats weighing 200–300 g underwent bilateral ovariectomy (OVX) and were fed soya free diet (n = 8 rats per group). In all groups: (Control, Control + Resveratrol, OVX and OVX + Resveratrol) resveratrol was administered orally at a dose of 5 mg/kg/day for 1 month. Glucose and other biochemical parameters were examined. RESULTS: Significant reduction in the gain of body weight was observed in the control rats treated with resveratrol. Ovariectomy caused an escalation in gain of body weight due to loss of estrogen which was brought down with resveratrol. There was a slight dip in the blood glucose levels after resveratrol treatment. CONCLUSION: Resveratrol significantly reduced the gain of body weight in the control rats and in OVX rats showing its antiobesogenic effects.
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spelling pubmed-53915492017-04-14 Resveratrol regulates body weight in healthy and ovariectomized rats Sharma, Rupali Sharma, Neel Kamal Thungapathra, M. Nutr Metab (Lond) Brief Communication OBJECTIVE: The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of the study was to explore the effects of RES on the body weight of ovariectomized (OVX) female rats with controls and to relate their biochemical parameters. METHODS: Female Wistar rats weighing 200–300 g underwent bilateral ovariectomy (OVX) and were fed soya free diet (n = 8 rats per group). In all groups: (Control, Control + Resveratrol, OVX and OVX + Resveratrol) resveratrol was administered orally at a dose of 5 mg/kg/day for 1 month. Glucose and other biochemical parameters were examined. RESULTS: Significant reduction in the gain of body weight was observed in the control rats treated with resveratrol. Ovariectomy caused an escalation in gain of body weight due to loss of estrogen which was brought down with resveratrol. There was a slight dip in the blood glucose levels after resveratrol treatment. CONCLUSION: Resveratrol significantly reduced the gain of body weight in the control rats and in OVX rats showing its antiobesogenic effects. BioMed Central 2017-04-14 /pmc/articles/PMC5391549/ /pubmed/28413432 http://dx.doi.org/10.1186/s12986-017-0183-5 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Brief Communication
Sharma, Rupali
Sharma, Neel Kamal
Thungapathra, M.
Resveratrol regulates body weight in healthy and ovariectomized rats
title Resveratrol regulates body weight in healthy and ovariectomized rats
title_full Resveratrol regulates body weight in healthy and ovariectomized rats
title_fullStr Resveratrol regulates body weight in healthy and ovariectomized rats
title_full_unstemmed Resveratrol regulates body weight in healthy and ovariectomized rats
title_short Resveratrol regulates body weight in healthy and ovariectomized rats
title_sort resveratrol regulates body weight in healthy and ovariectomized rats
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391549/
https://www.ncbi.nlm.nih.gov/pubmed/28413432
http://dx.doi.org/10.1186/s12986-017-0183-5
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