Cargando…

Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study

Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the production of common household and consumer goods for their nonflammable, lipophobic, and hydrophobic properties. Inverse associations between maternal or umbilical cord blood concentrations of pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Ashley-Martin, Jillian, Dodds, Linda, Arbuckle, Tye E., Bouchard, Maryse F., Fisher, Mandy, Morriset, Anne-Sophie, Monnier, Patricia, Shapiro, Gabriel D., Ettinger, Adrienne S., Dallaire, Renee, Taback, Shayne, Fraser, William, Platt, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391709/
https://www.ncbi.nlm.nih.gov/pubmed/28172036
http://dx.doi.org/10.1093/aje/kww213
_version_ 1783229325846249472
author Ashley-Martin, Jillian
Dodds, Linda
Arbuckle, Tye E.
Bouchard, Maryse F.
Fisher, Mandy
Morriset, Anne-Sophie
Monnier, Patricia
Shapiro, Gabriel D.
Ettinger, Adrienne S.
Dallaire, Renee
Taback, Shayne
Fraser, William
Platt, Robert W.
author_facet Ashley-Martin, Jillian
Dodds, Linda
Arbuckle, Tye E.
Bouchard, Maryse F.
Fisher, Mandy
Morriset, Anne-Sophie
Monnier, Patricia
Shapiro, Gabriel D.
Ettinger, Adrienne S.
Dallaire, Renee
Taback, Shayne
Fraser, William
Platt, Robert W.
author_sort Ashley-Martin, Jillian
collection PubMed
description Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the production of common household and consumer goods for their nonflammable, lipophobic, and hydrophobic properties. Inverse associations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfluorooctanesulfonate and birth weight have been identified. This literature has primarily examined each PFAS individually without consideration of the potential influence of correlated exposures. Further, the association between PFAS exposures and indicators of metabolic function (i.e., leptin and adiponectin) has received limited attention. We examined associations between first-trimester maternal plasma PFAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using data on 1,705 mother-infant pairs from the Maternal Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada birth cohort study that recruited women between 2008 and 2011. Bayesian hierarchical models were used to quantify associations and calculate credible intervals. Maternal perfluorooctanoic acid concentrations were inversely associated with birth weight z score, though the null value was included in all credible intervals (log(10) β = −0.10, 95% credible interval: −0.34, 0.13). All associations between maternal PFAS concentrations and cord blood adipocytokine concentrations were of small magnitude and centered around the null value. Follow-up in a cohort of children is required to determine how the observed associations manifest in childhood.
format Online
Article
Text
id pubmed-5391709
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-53917092017-04-24 Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study Ashley-Martin, Jillian Dodds, Linda Arbuckle, Tye E. Bouchard, Maryse F. Fisher, Mandy Morriset, Anne-Sophie Monnier, Patricia Shapiro, Gabriel D. Ettinger, Adrienne S. Dallaire, Renee Taback, Shayne Fraser, William Platt, Robert W. Am J Epidemiol Original Contributions Perfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals that have been widely used in the production of common household and consumer goods for their nonflammable, lipophobic, and hydrophobic properties. Inverse associations between maternal or umbilical cord blood concentrations of perfluorooctanoic acid and perfluorooctanesulfonate and birth weight have been identified. This literature has primarily examined each PFAS individually without consideration of the potential influence of correlated exposures. Further, the association between PFAS exposures and indicators of metabolic function (i.e., leptin and adiponectin) has received limited attention. We examined associations between first-trimester maternal plasma PFAS concentrations and birth weight and cord blood concentrations of leptin and adiponectin using data on 1,705 mother-infant pairs from the Maternal Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada birth cohort study that recruited women between 2008 and 2011. Bayesian hierarchical models were used to quantify associations and calculate credible intervals. Maternal perfluorooctanoic acid concentrations were inversely associated with birth weight z score, though the null value was included in all credible intervals (log(10) β = −0.10, 95% credible interval: −0.34, 0.13). All associations between maternal PFAS concentrations and cord blood adipocytokine concentrations were of small magnitude and centered around the null value. Follow-up in a cohort of children is required to determine how the observed associations manifest in childhood. Oxford University Press 2017-02-01 2017-02-01 /pmc/articles/PMC5391709/ /pubmed/28172036 http://dx.doi.org/10.1093/aje/kww213 Text en © The Author 2017. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journalpermissions@oup.com.
spellingShingle Original Contributions
Ashley-Martin, Jillian
Dodds, Linda
Arbuckle, Tye E.
Bouchard, Maryse F.
Fisher, Mandy
Morriset, Anne-Sophie
Monnier, Patricia
Shapiro, Gabriel D.
Ettinger, Adrienne S.
Dallaire, Renee
Taback, Shayne
Fraser, William
Platt, Robert W.
Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study
title Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study
title_full Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study
title_fullStr Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study
title_full_unstemmed Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study
title_short Maternal Concentrations of Perfluoroalkyl Substances and Fetal Markers of Metabolic Function and Birth Weight: The Maternal-Infant Research on Environmental Chemicals (MIREC) Study
title_sort maternal concentrations of perfluoroalkyl substances and fetal markers of metabolic function and birth weight: the maternal-infant research on environmental chemicals (mirec) study
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391709/
https://www.ncbi.nlm.nih.gov/pubmed/28172036
http://dx.doi.org/10.1093/aje/kww213
work_keys_str_mv AT ashleymartinjillian maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT doddslinda maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT arbuckletyee maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT bouchardmarysef maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT fishermandy maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT morrisetannesophie maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT monnierpatricia maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT shapirogabrield maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT ettingeradriennes maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT dallairerenee maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT tabackshayne maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT fraserwilliam maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy
AT plattrobertw maternalconcentrationsofperfluoroalkylsubstancesandfetalmarkersofmetabolicfunctionandbirthweightthematernalinfantresearchonenvironmentalchemicalsmirecstudy