Cyclin D mediates tolerance of genome-doubling in cancers with functional p53

BACKGROUND: Aneuploidy and chromosomal instability (CIN) are common features of human malignancy that fuel genetic heterogeneity. Although tolerance to tetraploidization, an intermediate state that further exacerbates CIN, is frequently mediated by TP53 dysfunction, we find that some genome-doubled...

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Detalles Bibliográficos
Autores principales: Crockford, A., Zalmas, L. P., Grönroos, E., Dewhurst, S. M., McGranahan, N., Cuomo, M. E., Encheva, V., Snijders, A. P., Begum, J., Purewal, S., Cerveira, J., Patel, H., Renshaw, M. J., Swanton, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391719/
https://www.ncbi.nlm.nih.gov/pubmed/28177473
http://dx.doi.org/10.1093/annonc/mdw612

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