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IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety

Background: The significant risk of adverse events following medical procedures supports a clinical epidemiological approach based on the analyses of collections of electronic medical records. Data analytical tools might help clinical epidemiologists develop more appropriate case-crossover designs f...

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Autores principales: Caron, Alexandre, Chazard, Emmanuel, Muller, Joris, Perichon, Renaud, Ferret, Laurie, Koutkias, Vassilis, Beuscart, Régis, Beuscart, Jean-Baptiste, Ficheur, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391728/
https://www.ncbi.nlm.nih.gov/pubmed/27678461
http://dx.doi.org/10.1093/jamia/ocw132
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author Caron, Alexandre
Chazard, Emmanuel
Muller, Joris
Perichon, Renaud
Ferret, Laurie
Koutkias, Vassilis
Beuscart, Régis
Beuscart, Jean-Baptiste
Ficheur, Grégoire
author_facet Caron, Alexandre
Chazard, Emmanuel
Muller, Joris
Perichon, Renaud
Ferret, Laurie
Koutkias, Vassilis
Beuscart, Régis
Beuscart, Jean-Baptiste
Ficheur, Grégoire
author_sort Caron, Alexandre
collection PubMed
description Background: The significant risk of adverse events following medical procedures supports a clinical epidemiological approach based on the analyses of collections of electronic medical records. Data analytical tools might help clinical epidemiologists develop more appropriate case-crossover designs for monitoring patient safety. Objective: To develop and assess the methodological quality of an interactive tool for use by clinical epidemiologists to systematically design case-crossover analyses of large electronic medical records databases. Material and Methods: We developed IT-CARES, an analytical tool implementing case-crossover design, to explore the association between exposures and outcomes. The exposures and outcomes are defined by clinical epidemiologists via lists of codes entered via a user interface screen. We tested IT-CARES on data from the French national inpatient stay database, which documents diagnoses and medical procedures for 170 million inpatient stays between 2007 and 2013. We compared the results of our analysis with reference data from the literature on thromboembolic risk after delivery and bleeding risk after total hip replacement. Results: IT-CARES provides a user interface with 3 columns: (i) the outcome criteria in the left-hand column, (ii) the exposure criteria in the right-hand column, and (iii) the estimated risk (odds ratios, presented in both graphical and tabular formats) in the middle column. The estimated odds ratios were consistent with the reference literature data. Discussion: IT-CARES may enhance patient safety by facilitating clinical epidemiological studies of adverse events following medical procedures. The tool’s usability must be evaluated and improved in further research.
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spelling pubmed-53917282017-04-21 IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety Caron, Alexandre Chazard, Emmanuel Muller, Joris Perichon, Renaud Ferret, Laurie Koutkias, Vassilis Beuscart, Régis Beuscart, Jean-Baptiste Ficheur, Grégoire J Am Med Inform Assoc Research and Applications Background: The significant risk of adverse events following medical procedures supports a clinical epidemiological approach based on the analyses of collections of electronic medical records. Data analytical tools might help clinical epidemiologists develop more appropriate case-crossover designs for monitoring patient safety. Objective: To develop and assess the methodological quality of an interactive tool for use by clinical epidemiologists to systematically design case-crossover analyses of large electronic medical records databases. Material and Methods: We developed IT-CARES, an analytical tool implementing case-crossover design, to explore the association between exposures and outcomes. The exposures and outcomes are defined by clinical epidemiologists via lists of codes entered via a user interface screen. We tested IT-CARES on data from the French national inpatient stay database, which documents diagnoses and medical procedures for 170 million inpatient stays between 2007 and 2013. We compared the results of our analysis with reference data from the literature on thromboembolic risk after delivery and bleeding risk after total hip replacement. Results: IT-CARES provides a user interface with 3 columns: (i) the outcome criteria in the left-hand column, (ii) the exposure criteria in the right-hand column, and (iii) the estimated risk (odds ratios, presented in both graphical and tabular formats) in the middle column. The estimated odds ratios were consistent with the reference literature data. Discussion: IT-CARES may enhance patient safety by facilitating clinical epidemiological studies of adverse events following medical procedures. The tool’s usability must be evaluated and improved in further research. Oxford University Press 2017-03 2016-09-27 /pmc/articles/PMC5391728/ /pubmed/27678461 http://dx.doi.org/10.1093/jamia/ocw132 Text en © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Research and Applications
Caron, Alexandre
Chazard, Emmanuel
Muller, Joris
Perichon, Renaud
Ferret, Laurie
Koutkias, Vassilis
Beuscart, Régis
Beuscart, Jean-Baptiste
Ficheur, Grégoire
IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
title IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
title_full IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
title_fullStr IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
title_full_unstemmed IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
title_short IT-CARES: an interactive tool for case-crossover analyses of electronic medical records for patient safety
title_sort it-cares: an interactive tool for case-crossover analyses of electronic medical records for patient safety
topic Research and Applications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391728/
https://www.ncbi.nlm.nih.gov/pubmed/27678461
http://dx.doi.org/10.1093/jamia/ocw132
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