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Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin

IN BRIEF Many patients with type 2 diabetes require high basal insulin doses, necessitating multiple injections, increasing patient burden, and resulting in reduced treatment adherence. This randomized, controlled, crossover trial compared the efficacy, safety, and patient-reported outcomes for a co...

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Autores principales: Warren, Mark L., Chaykin, Louis B., Jabbour, Serge, Sheikh-Ali, Mae, Hansen, Charlotte T., Nielsen, Thor S.S., Norwood, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391813/
https://www.ncbi.nlm.nih.gov/pubmed/28442823
http://dx.doi.org/10.2337/cd15-0058
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author Warren, Mark L.
Chaykin, Louis B.
Jabbour, Serge
Sheikh-Ali, Mae
Hansen, Charlotte T.
Nielsen, Thor S.S.
Norwood, Paul
author_facet Warren, Mark L.
Chaykin, Louis B.
Jabbour, Serge
Sheikh-Ali, Mae
Hansen, Charlotte T.
Nielsen, Thor S.S.
Norwood, Paul
author_sort Warren, Mark L.
collection PubMed
description IN BRIEF Many patients with type 2 diabetes require high basal insulin doses, necessitating multiple injections, increasing patient burden, and resulting in reduced treatment adherence. This randomized, controlled, crossover trial compared the efficacy, safety, and patient-reported outcomes for a concentrated formulation of insulin degludec (200 units/mL) to those of insulin glargine in patients requiring high doses of basal insulin. By offering equivalent glycemic control while reducing the rate of confirmed hypoglycemia and the number of injections required for administration, insulin degludec 200 units/mL may be preferred by patients with type 2 diabetes who require high basal insulin doses.
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spelling pubmed-53918132018-04-01 Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin Warren, Mark L. Chaykin, Louis B. Jabbour, Serge Sheikh-Ali, Mae Hansen, Charlotte T. Nielsen, Thor S.S. Norwood, Paul Clin Diabetes Feature Articles IN BRIEF Many patients with type 2 diabetes require high basal insulin doses, necessitating multiple injections, increasing patient burden, and resulting in reduced treatment adherence. This randomized, controlled, crossover trial compared the efficacy, safety, and patient-reported outcomes for a concentrated formulation of insulin degludec (200 units/mL) to those of insulin glargine in patients requiring high doses of basal insulin. By offering equivalent glycemic control while reducing the rate of confirmed hypoglycemia and the number of injections required for administration, insulin degludec 200 units/mL may be preferred by patients with type 2 diabetes who require high basal insulin doses. American Diabetes Association 2017-04 /pmc/articles/PMC5391813/ /pubmed/28442823 http://dx.doi.org/10.2337/cd15-0058 Text en © 2017 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details.
spellingShingle Feature Articles
Warren, Mark L.
Chaykin, Louis B.
Jabbour, Serge
Sheikh-Ali, Mae
Hansen, Charlotte T.
Nielsen, Thor S.S.
Norwood, Paul
Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
title Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
title_full Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
title_fullStr Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
title_full_unstemmed Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
title_short Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
title_sort insulin degludec 200 units/ml is associated with lower injection frequency and improved patient-reported outcomes compared with insulin glargine 100 units/ml in patients with type 2 diabetes requiring high-dose insulin
topic Feature Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391813/
https://www.ncbi.nlm.nih.gov/pubmed/28442823
http://dx.doi.org/10.2337/cd15-0058
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