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Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
IN BRIEF Many patients with type 2 diabetes require high basal insulin doses, necessitating multiple injections, increasing patient burden, and resulting in reduced treatment adherence. This randomized, controlled, crossover trial compared the efficacy, safety, and patient-reported outcomes for a co...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Diabetes Association
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391813/ https://www.ncbi.nlm.nih.gov/pubmed/28442823 http://dx.doi.org/10.2337/cd15-0058 |
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author | Warren, Mark L. Chaykin, Louis B. Jabbour, Serge Sheikh-Ali, Mae Hansen, Charlotte T. Nielsen, Thor S.S. Norwood, Paul |
author_facet | Warren, Mark L. Chaykin, Louis B. Jabbour, Serge Sheikh-Ali, Mae Hansen, Charlotte T. Nielsen, Thor S.S. Norwood, Paul |
author_sort | Warren, Mark L. |
collection | PubMed |
description | IN BRIEF Many patients with type 2 diabetes require high basal insulin doses, necessitating multiple injections, increasing patient burden, and resulting in reduced treatment adherence. This randomized, controlled, crossover trial compared the efficacy, safety, and patient-reported outcomes for a concentrated formulation of insulin degludec (200 units/mL) to those of insulin glargine in patients requiring high doses of basal insulin. By offering equivalent glycemic control while reducing the rate of confirmed hypoglycemia and the number of injections required for administration, insulin degludec 200 units/mL may be preferred by patients with type 2 diabetes who require high basal insulin doses. |
format | Online Article Text |
id | pubmed-5391813 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-53918132018-04-01 Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin Warren, Mark L. Chaykin, Louis B. Jabbour, Serge Sheikh-Ali, Mae Hansen, Charlotte T. Nielsen, Thor S.S. Norwood, Paul Clin Diabetes Feature Articles IN BRIEF Many patients with type 2 diabetes require high basal insulin doses, necessitating multiple injections, increasing patient burden, and resulting in reduced treatment adherence. This randomized, controlled, crossover trial compared the efficacy, safety, and patient-reported outcomes for a concentrated formulation of insulin degludec (200 units/mL) to those of insulin glargine in patients requiring high doses of basal insulin. By offering equivalent glycemic control while reducing the rate of confirmed hypoglycemia and the number of injections required for administration, insulin degludec 200 units/mL may be preferred by patients with type 2 diabetes who require high basal insulin doses. American Diabetes Association 2017-04 /pmc/articles/PMC5391813/ /pubmed/28442823 http://dx.doi.org/10.2337/cd15-0058 Text en © 2017 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0 for details. |
spellingShingle | Feature Articles Warren, Mark L. Chaykin, Louis B. Jabbour, Serge Sheikh-Ali, Mae Hansen, Charlotte T. Nielsen, Thor S.S. Norwood, Paul Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin |
title | Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin |
title_full | Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin |
title_fullStr | Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin |
title_full_unstemmed | Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin |
title_short | Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin |
title_sort | insulin degludec 200 units/ml is associated with lower injection frequency and improved patient-reported outcomes compared with insulin glargine 100 units/ml in patients with type 2 diabetes requiring high-dose insulin |
topic | Feature Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391813/ https://www.ncbi.nlm.nih.gov/pubmed/28442823 http://dx.doi.org/10.2337/cd15-0058 |
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