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The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis
People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology. Forty-six adults with DS un...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391869/ https://www.ncbi.nlm.nih.gov/pubmed/28192686 http://dx.doi.org/10.1016/j.neurobiolaging.2017.01.009 |
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author | Annus, Tiina Wilson, Liam R. Acosta-Cabronero, Julio Cardenas-Blanco, Arturo Hong, Young T. Fryer, Tim D. Coles, Jonathan P. Menon, David K. Zaman, Shahid H. Holland, Anthony J. Nestor, Peter J. |
author_facet | Annus, Tiina Wilson, Liam R. Acosta-Cabronero, Julio Cardenas-Blanco, Arturo Hong, Young T. Fryer, Tim D. Coles, Jonathan P. Menon, David K. Zaman, Shahid H. Holland, Anthony J. Nestor, Peter J. |
author_sort | Annus, Tiina |
collection | PubMed |
description | People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology. Forty-six adults with DS underwent structural and amyloid imaging—the latter using Pittsburgh compound B (PIB) to stratify the cohort into PIB-positive (n = 19) and PIB-negative (n = 27). Age-matched controls (n = 30) underwent structural imaging. Group differences in deep gray matter volumetry and cortical thickness were studied. PIB-negative people with DS have neurodevelopmentally atypical brain, characterized by disproportionately thicker frontal and occipitoparietal cortex and thinner motor cortex and temporal pole with larger putamina and smaller hippocampi than controls. In the presence of amyloid neuropathology, the DS brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-DS Alzheimer's disease. Care must be taken to avoid underestimating amyloid-associated morphologic changes in DS due to disproportionate size of some subcortical structures and thickness of the cortex. |
format | Online Article Text |
id | pubmed-5391869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-53918692017-05-01 The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis Annus, Tiina Wilson, Liam R. Acosta-Cabronero, Julio Cardenas-Blanco, Arturo Hong, Young T. Fryer, Tim D. Coles, Jonathan P. Menon, David K. Zaman, Shahid H. Holland, Anthony J. Nestor, Peter J. Neurobiol Aging Regular Article People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology. Forty-six adults with DS underwent structural and amyloid imaging—the latter using Pittsburgh compound B (PIB) to stratify the cohort into PIB-positive (n = 19) and PIB-negative (n = 27). Age-matched controls (n = 30) underwent structural imaging. Group differences in deep gray matter volumetry and cortical thickness were studied. PIB-negative people with DS have neurodevelopmentally atypical brain, characterized by disproportionately thicker frontal and occipitoparietal cortex and thinner motor cortex and temporal pole with larger putamina and smaller hippocampi than controls. In the presence of amyloid neuropathology, the DS brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-DS Alzheimer's disease. Care must be taken to avoid underestimating amyloid-associated morphologic changes in DS due to disproportionate size of some subcortical structures and thickness of the cortex. Elsevier 2017-05 /pmc/articles/PMC5391869/ /pubmed/28192686 http://dx.doi.org/10.1016/j.neurobiolaging.2017.01.009 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Regular Article Annus, Tiina Wilson, Liam R. Acosta-Cabronero, Julio Cardenas-Blanco, Arturo Hong, Young T. Fryer, Tim D. Coles, Jonathan P. Menon, David K. Zaman, Shahid H. Holland, Anthony J. Nestor, Peter J. The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
title | The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
title_full | The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
title_fullStr | The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
title_full_unstemmed | The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
title_short | The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
title_sort | down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391869/ https://www.ncbi.nlm.nih.gov/pubmed/28192686 http://dx.doi.org/10.1016/j.neurobiolaging.2017.01.009 |
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