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An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes

High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate...

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Autores principales: Hicks, Chindo, Ramani, Ritika, Sartor, Oliver, Bhalla, Ritu, Miele, Lucio, Dlamini, Zodwa, Gumede, Njabulo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391982/
https://www.ncbi.nlm.nih.gov/pubmed/28469398
http://dx.doi.org/10.1177/1177271917695810
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author Hicks, Chindo
Ramani, Ritika
Sartor, Oliver
Bhalla, Ritu
Miele, Lucio
Dlamini, Zodwa
Gumede, Njabulo
author_facet Hicks, Chindo
Ramani, Ritika
Sartor, Oliver
Bhalla, Ritu
Miele, Lucio
Dlamini, Zodwa
Gumede, Njabulo
author_sort Hicks, Chindo
collection PubMed
description High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups. In addition, the analysis revealed molecular networks and biological pathways enriched for genetic susceptibility variants. The discovered pathways include the androgen, apoptosis, and insulinlike growth factor signaling pathways. This analysis established putative functional bridges between GWAS discoveries and the biological pathways involved in primary organ–confined and metastatic prostate cancer.
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spelling pubmed-53919822017-05-03 An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes Hicks, Chindo Ramani, Ritika Sartor, Oliver Bhalla, Ritu Miele, Lucio Dlamini, Zodwa Gumede, Njabulo Biomark Insights Original Research High-throughput genotyping has enabled discovery of genetic variants associated with an increased risk of developing prostate cancer using genome-wide association studies (GWAS). The goal of this study was to associate GWAS information of patients with primary organ–confined and metastatic prostate cancer using gene expression data and to identify molecular networks and biological pathways enriched for genetic susceptibility variants involved in the 2 disease states. The analysis revealed gene signatures for the 2 disease states and a gene signature distinguishing the 2 patient groups. In addition, the analysis revealed molecular networks and biological pathways enriched for genetic susceptibility variants. The discovered pathways include the androgen, apoptosis, and insulinlike growth factor signaling pathways. This analysis established putative functional bridges between GWAS discoveries and the biological pathways involved in primary organ–confined and metastatic prostate cancer. SAGE Publications 2017-03-16 /pmc/articles/PMC5391982/ /pubmed/28469398 http://dx.doi.org/10.1177/1177271917695810 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Original Research
Hicks, Chindo
Ramani, Ritika
Sartor, Oliver
Bhalla, Ritu
Miele, Lucio
Dlamini, Zodwa
Gumede, Njabulo
An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_full An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_fullStr An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_full_unstemmed An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_short An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes
title_sort integrative genomics approach for associating genome-wide association studies information with localized and metastatic prostate cancer phenotypes
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391982/
https://www.ncbi.nlm.nih.gov/pubmed/28469398
http://dx.doi.org/10.1177/1177271917695810
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