Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation

Malignant peripheral nerve sheath tumor (MPNST) and neuroblastoma models respond to the investigational small molecule Aurora A kinase inhibitor, alisertib. We previously reported that MPNST and neuroblastomas are also susceptible to oncolytic herpes virus (oHSV) therapy. Herein, we show that combin...

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Detalles Bibliográficos
Autores principales: Currier, Mark A., Sprague, Les, Rizvi, Tilat A., Nartker, Brooke, Chen, Chun-Yu, Wang, Pin-Yi, Hutzen, Brian J., Franczek, Meghan R., Patel, Ami V., Chaney, Katherine E., Streby, Keri A., Ecsedy, Jeffrey A., Conner, Joe, Ratner, Nancy, Cripe, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392259/
https://www.ncbi.nlm.nih.gov/pubmed/28147331
http://dx.doi.org/10.18632/oncotarget.14885

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