Altered bone marrow lymphopoiesis and interleukin-6-dependent inhibition of thymocyte differentiation contribute to thymic atrophy during Trypanosoma cruzi infection

Thymic atrophy occurs during infection being associated with apoptosis of double positive (DP) and premature exit of DP and double negative (DN) thymocytes. We observed for the first time that a significant bone marrow aplasia and a decrease in common lymphoid progenitors (CLPs) preceded thymic alte...

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Detalles Bibliográficos
Autores principales: Carbajosa, Sofía, Gea, Susana, Chillón-arinas, Carlos, Poveda, Cristina, Maza, María del Carmen, Fresno, Manuel, Gironès, Núria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392268/
https://www.ncbi.nlm.nih.gov/pubmed/28147332
http://dx.doi.org/10.18632/oncotarget.14886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392268/
https://www.ncbi.nlm.nih.gov/pubmed/28147332
http://dx.doi.org/10.18632/oncotarget.14886

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