Using high-sensitivity sequencing for the detection of mutations in BTK and PLCγ2 genes in cellular and cell-free DNA and correlation with progression in patients treated with BTK inhibitors

Patients with chronic lymphocytic leukemia (CLL) that develop resistance to Bruton tyrosine kinase (BTK) inhibitors are typically positive for mutations in BTK or phospholipase c gamma 2 (PLCγ2). We developed a high sensitivity (HS) assay utilizing wild-type blocking polymerase chain reaction achiev...

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Detalles Bibliográficos
Autores principales: Albitar, Adam, Ma, Wanlong, DeDios, Ivan, Estella, Jeffrey, Ahn, Inhye, Farooqui, Mohammed, Wiestner, Adrian, Albitar, Maher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392298/
https://www.ncbi.nlm.nih.gov/pubmed/28212557
http://dx.doi.org/10.18632/oncotarget.15316

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