The Rrp4-exosome complex recruits and channels substrate RNA by a unique mechanism

The exosome is a large molecular machine that is involved in RNA degradation and processing. Here, we address how the trimeric Rrp4 cap enhances the activity of the archaeal enzyme complex. Using methyl TROSY NMR methods we identified a 50 Å long RNA binding path on each Rrp4 protomer. We show that...

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Detalles Bibliográficos
Autores principales: Cvetkovic, Milos A., Wurm, Jan Philip, Audin, Maxime J., Schütz, Stefan, Sprangers, Remco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392361/
https://www.ncbi.nlm.nih.gov/pubmed/28288106
http://dx.doi.org/10.1038/nchembio.2328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392361/
https://www.ncbi.nlm.nih.gov/pubmed/28288106
http://dx.doi.org/10.1038/nchembio.2328

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