Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels

Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n = 125). Th...

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Autores principales: Macek Jilkova, Zuzana, Decaens, Thomas, Marlu, Alice, Marche, Hélène, Jouvin-Marche, Evelyne, Marche, Patrice N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392396/
https://www.ncbi.nlm.nih.gov/pubmed/28469292
http://dx.doi.org/10.1155/2017/3214917
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author Macek Jilkova, Zuzana
Decaens, Thomas
Marlu, Alice
Marche, Hélène
Jouvin-Marche, Evelyne
Marche, Patrice N.
author_facet Macek Jilkova, Zuzana
Decaens, Thomas
Marlu, Alice
Marche, Hélène
Jouvin-Marche, Evelyne
Marche, Patrice N.
author_sort Macek Jilkova, Zuzana
collection PubMed
description Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n = 125). The frequency of CD107(+) NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p = 0.002) and correlated with the plasma levels of estradiol (correlation coefficient r = 0.634; p < 0.0001). Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients. This probably contributes to the ability of females to better deal with HBV disease.
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spelling pubmed-53923962017-05-03 Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels Macek Jilkova, Zuzana Decaens, Thomas Marlu, Alice Marche, Hélène Jouvin-Marche, Evelyne Marche, Patrice N. Mediators Inflamm Research Article Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n = 125). The frequency of CD107(+) NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p = 0.002) and correlated with the plasma levels of estradiol (correlation coefficient r = 0.634; p < 0.0001). Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients. This probably contributes to the ability of females to better deal with HBV disease. Hindawi 2017 2017-04-02 /pmc/articles/PMC5392396/ /pubmed/28469292 http://dx.doi.org/10.1155/2017/3214917 Text en Copyright © 2017 Zuzana Macek Jilkova et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Macek Jilkova, Zuzana
Decaens, Thomas
Marlu, Alice
Marche, Hélène
Jouvin-Marche, Evelyne
Marche, Patrice N.
Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
title Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
title_full Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
title_fullStr Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
title_full_unstemmed Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
title_short Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
title_sort sex differences in spontaneous degranulation activity of intrahepatic natural killer cells during chronic hepatitis b: association with estradiol levels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392396/
https://www.ncbi.nlm.nih.gov/pubmed/28469292
http://dx.doi.org/10.1155/2017/3214917
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