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A model for the conformational activation of the structurally quiescent metalloprotease ADAMTS13 by von willebrand factor

Blood loss is prevented by the multidomain glycoprotein von Willebrand factor (VWF), which binds exposed collagen at damaged vessels and captures platelets. VWF is regulated by the metalloprotease ADAMTS13, which in turn is conformationally activated by VWF. To delineate the structural requirements...

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Detalles Bibliográficos
Autores principales:	South, Kieron, Freitas, Marta O., Lane, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2017
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392571/ https://www.ncbi.nlm.nih.gov/pubmed/28209710 http://dx.doi.org/10.1074/jbc.M117.776732

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