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At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces

The multimammate mouse (Mastomys natalensis) is the reservoir for Lassa virus (LASV). Zoonotic transmission occurs when humans are directly or indirectly exposed to fluids of the multimammate mouse, such as urine, saliva, and blood. Housing characteristics and domestic organization affect rodent den...

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Autores principales: Bonwitt, Jesse, Sáez, Almudena Mari, Lamin, Joseph, Ansumana, Rashid, Dawson, Michael, Buanie, Jacob, Lamin, Joyce, Sondufu, Diana, Borchert, Matthias, Sahr, Foday, Fichet-Calvet, Elisabeth, Brown, Hannah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392645/
https://www.ncbi.nlm.nih.gov/pubmed/28167603
http://dx.doi.org/10.4269/ajtmh.16-0675
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author Bonwitt, Jesse
Sáez, Almudena Mari
Lamin, Joseph
Ansumana, Rashid
Dawson, Michael
Buanie, Jacob
Lamin, Joyce
Sondufu, Diana
Borchert, Matthias
Sahr, Foday
Fichet-Calvet, Elisabeth
Brown, Hannah
author_facet Bonwitt, Jesse
Sáez, Almudena Mari
Lamin, Joseph
Ansumana, Rashid
Dawson, Michael
Buanie, Jacob
Lamin, Joyce
Sondufu, Diana
Borchert, Matthias
Sahr, Foday
Fichet-Calvet, Elisabeth
Brown, Hannah
author_sort Bonwitt, Jesse
collection PubMed
description The multimammate mouse (Mastomys natalensis) is the reservoir for Lassa virus (LASV). Zoonotic transmission occurs when humans are directly or indirectly exposed to fluids of the multimammate mouse, such as urine, saliva, and blood. Housing characteristics and domestic organization affect rodent density in and around households and villages, and are likely to be a risk factor for Lassa fever in humans where the reservoir exists. We use semi-structured interviews (N = 51), a quantitative survey (N = 429), direct observations, and a rodent ecology study to provide new insights into how the organization of domestic spaces brings together humans and rodents and creates pathways for infection in rural settlements in Bo District, Sierra Leone. Rodents were frequently reported inside houses (92.4% of respondents), in which we predominantly trapped M. natalensis (57% of trapped rodents) and Rattus rattus (38% of trapped rodents). Building design and materials provide hiding and nesting places for rodents and lead to close proximity with humans. Patterns of contact are both unintentional and intentional and research participants reported high levels of contact with rodents (34.2% of respondents) and rodent fluids (52.8% of respondents). Rodents are also perceived as a serious threat to food security. These results present detailed knowledge about how humans live with and come into contact with rodents, including the LASV reservoir. Our results argue for further collaborative research in housing and environmental modification such as ceiling construction, food storage, and sanitation as prevention against zoonotic LASV transmission.
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spelling pubmed-53926452017-04-20 At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces Bonwitt, Jesse Sáez, Almudena Mari Lamin, Joseph Ansumana, Rashid Dawson, Michael Buanie, Jacob Lamin, Joyce Sondufu, Diana Borchert, Matthias Sahr, Foday Fichet-Calvet, Elisabeth Brown, Hannah Am J Trop Med Hyg Articles The multimammate mouse (Mastomys natalensis) is the reservoir for Lassa virus (LASV). Zoonotic transmission occurs when humans are directly or indirectly exposed to fluids of the multimammate mouse, such as urine, saliva, and blood. Housing characteristics and domestic organization affect rodent density in and around households and villages, and are likely to be a risk factor for Lassa fever in humans where the reservoir exists. We use semi-structured interviews (N = 51), a quantitative survey (N = 429), direct observations, and a rodent ecology study to provide new insights into how the organization of domestic spaces brings together humans and rodents and creates pathways for infection in rural settlements in Bo District, Sierra Leone. Rodents were frequently reported inside houses (92.4% of respondents), in which we predominantly trapped M. natalensis (57% of trapped rodents) and Rattus rattus (38% of trapped rodents). Building design and materials provide hiding and nesting places for rodents and lead to close proximity with humans. Patterns of contact are both unintentional and intentional and research participants reported high levels of contact with rodents (34.2% of respondents) and rodent fluids (52.8% of respondents). Rodents are also perceived as a serious threat to food security. These results present detailed knowledge about how humans live with and come into contact with rodents, including the LASV reservoir. Our results argue for further collaborative research in housing and environmental modification such as ceiling construction, food storage, and sanitation as prevention against zoonotic LASV transmission. The American Society of Tropical Medicine and Hygiene 2017-04-05 /pmc/articles/PMC5392645/ /pubmed/28167603 http://dx.doi.org/10.4269/ajtmh.16-0675 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Bonwitt, Jesse
Sáez, Almudena Mari
Lamin, Joseph
Ansumana, Rashid
Dawson, Michael
Buanie, Jacob
Lamin, Joyce
Sondufu, Diana
Borchert, Matthias
Sahr, Foday
Fichet-Calvet, Elisabeth
Brown, Hannah
At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces
title At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces
title_full At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces
title_fullStr At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces
title_full_unstemmed At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces
title_short At Home with Mastomys and Rattus: Human-Rodent Interactions and Potential for Primary Transmission of Lassa Virus in Domestic Spaces
title_sort at home with mastomys and rattus: human-rodent interactions and potential for primary transmission of lassa virus in domestic spaces
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392645/
https://www.ncbi.nlm.nih.gov/pubmed/28167603
http://dx.doi.org/10.4269/ajtmh.16-0675
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