Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

[Image: see text] Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of malaria. We recently reported the identification of novel compounds derived from diversity-oriented synthesis with activit...

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Detalles Bibliográficos
Autores principales: Maetani, Micah, Kato, Nobutaka, Jabor, Valquiria A. P., Calil, Felipe A., Nonato, Maria Cristina, Scherer, Christina A., Schreiber, Stuart L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392761/
https://www.ncbi.nlm.nih.gov/pubmed/28435533
http://dx.doi.org/10.1021/acsmedchemlett.7b00030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392761/
https://www.ncbi.nlm.nih.gov/pubmed/28435533
http://dx.doi.org/10.1021/acsmedchemlett.7b00030

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