A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report

A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Cast...

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Autores principales: Mikumo, Hironori, Hamada, Naoki, Harada, Eiji, Yanagihara, Toyoshi, Ogata, Saiko, Yabuuchi, Hidetake, Ijichi, Kayo, Takayama, Koichi, Nakanishi, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392773/
https://www.ncbi.nlm.nih.gov/pubmed/28443233
http://dx.doi.org/10.1016/j.rmcr.2017.03.023
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author Mikumo, Hironori
Hamada, Naoki
Harada, Eiji
Yanagihara, Toyoshi
Ogata, Saiko
Yabuuchi, Hidetake
Ijichi, Kayo
Takayama, Koichi
Nakanishi, Yoichi
author_facet Mikumo, Hironori
Hamada, Naoki
Harada, Eiji
Yanagihara, Toyoshi
Ogata, Saiko
Yabuuchi, Hidetake
Ijichi, Kayo
Takayama, Koichi
Nakanishi, Yoichi
author_sort Mikumo, Hironori
collection PubMed
description A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S(6) biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation.
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spelling pubmed-53927732017-04-25 A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report Mikumo, Hironori Hamada, Naoki Harada, Eiji Yanagihara, Toyoshi Ogata, Saiko Yabuuchi, Hidetake Ijichi, Kayo Takayama, Koichi Nakanishi, Yoichi Respir Med Case Rep Case Report A 48-year-old man was admitted for evaluation of abnormal shadows on chest radiograph. Chest computed tomography (CT) showed cysts, nodules, and cervical and axillary lymphadenopathies. Elevated serum levels of IgG4 and interleukin (IL)-6 suggested IgG4-related disease (IgG4-RD) or multicentric Castleman's disease (MCD). Histologic findings of the cervical lymph node and right lung S(6) biopsies revealed numerous IgG4-positive plasma cells. Although CT findings of the lungs were atypical for IgG4-RD, consistent histologic findings, clinical symptoms, and laboratory data made us conclude IgG4-RD. Because histologic findings of IgG4-RD and MCD have similarities, differentiating between the two diseases should consider the clinical presentation. Elsevier 2017-04-08 /pmc/articles/PMC5392773/ /pubmed/28443233 http://dx.doi.org/10.1016/j.rmcr.2017.03.023 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Mikumo, Hironori
Hamada, Naoki
Harada, Eiji
Yanagihara, Toyoshi
Ogata, Saiko
Yabuuchi, Hidetake
Ijichi, Kayo
Takayama, Koichi
Nakanishi, Yoichi
A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
title A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
title_full A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
title_fullStr A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
title_full_unstemmed A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
title_short A case of immunoglobulin G4-related respiratory disease with multiple lung cysts: A case report
title_sort case of immunoglobulin g4-related respiratory disease with multiple lung cysts: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392773/
https://www.ncbi.nlm.nih.gov/pubmed/28443233
http://dx.doi.org/10.1016/j.rmcr.2017.03.023
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