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Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterized by a high rate of histone H3 mutation, resulting in repla...

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Detalles Bibliográficos
Autores principales:	Huang, Tina Y., Piunti, Andrea, Lulla, Rishi R., Qi, Jin, Horbinski, Craig M., Tomita, Tadanori, James, C. David, Shilatifard, Ali, Saratsis, Amanda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392913/ https://www.ncbi.nlm.nih.gov/pubmed/28416018 http://dx.doi.org/10.1186/s40478-017-0436-6

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