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Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

BACKGROUND: APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase elevating virus (LDV), a potent type I interferon inducer. Previously, we showed tha...

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Detalles Bibliográficos
Autores principales:	Barrett, Bradley S., Harper, Michael S., Jones, Sean T., Guo, Kejun, Heilman, Karl J., Kedl, Ross M., Hasenkrug, Kim J., Santiago, Mario L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392950/ https://www.ncbi.nlm.nih.gov/pubmed/28415995 http://dx.doi.org/10.1186/s12977-017-0349-2

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