Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

BACKGROUND: Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefore a promising target for GBM treatment. Our group identified the cellular prio...

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Detalles Bibliográficos
Autores principales: Iglesia, Rebeca Piatniczka, Prado, Mariana Brandão, Cruz, Lilian, Martins, Vilma Regina, Santos, Tiago Góss, Lopes, Marilene Hohmuth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392955/
https://www.ncbi.nlm.nih.gov/pubmed/28412969
http://dx.doi.org/10.1186/s13287-017-0518-1

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