Impact of the MDM2 splice-variants MDM2-A, MDM2-B and MDM2-C on cytotoxic stress response in breast cancer cells

BACKGROUND: The murine double minute 2 (MDM2) is an oncogene and a negative regulator of the tumor suppressor protein p53. MDM2 is known to be amplified in numerous human cancers, and upregulation of MDM2 is considered to be an alternative mechanism of p53 inactivation. The presence of many splice v...

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Detalles Bibliográficos
Autores principales: Huun, Johanna, Gansmo, Liv B., Mannsåker, Bård, Iversen, Gjertrud Titlestad, Øvrebø, Jan Inge, Lønning, Per E., Knappskog, Stian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393014/
https://www.ncbi.nlm.nih.gov/pubmed/28415963
http://dx.doi.org/10.1186/s12860-017-0134-z

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