BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method

Rapid advances in genetics are linking mutations on genes to diseases at an exponential rate, yet characterizing the gene-mutation-cell-behavior relationships essential for precision medicine remains a daunting task. More than 350 mutations on BRaf are associated with various tumors, and ∼40 mutatio...

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Detalles Bibliográficos
Autores principales: Lim, Chae-Seok, Kang, Xi, Mirabella, Vincent, Zhang, Huaye, Bu, Qian, Araki, Yoichi, Hoang, Elizabeth T., Wang, Shiqiang, Shen, Ying, Choi, Sukwoo, Kaang, Bong-Kiun, Chang, Qiang, Pang, Zhiping P., Huganir, Richard L., Zhu, J. Julius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393050/
https://www.ncbi.nlm.nih.gov/pubmed/28404629
http://dx.doi.org/10.1101/gad.294413.116

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