DNMT1 mutations found in HSANIE patients affect interaction with UHRF1 and neuronal differentiation

DNMT1 is recruited to substrate sites by PCNA and UHRF1 to maintain DNA methylation after replication. The cell cycle dependent recruitment of DNMT1 is mediated by the PCNA-binding domain (PBD) and the targeting sequence (TS) within the N-terminal regulatory domain. The TS domain was found to be mut...

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Detalles Bibliográficos
Autores principales: Smets, Martha, Link, Stephanie, Wolf, Patricia, Schneider, Katrin, Solis, Veronica, Ryan, Joel, Meilinger, Daniela, Qin, Weihua, Leonhardt, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393148/
https://www.ncbi.nlm.nih.gov/pubmed/28334952
http://dx.doi.org/10.1093/hmg/ddx057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393148/
https://www.ncbi.nlm.nih.gov/pubmed/28334952
http://dx.doi.org/10.1093/hmg/ddx057

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